雷公藤多苷联合白芍总苷治疗干燥综合征的临床效果观察及对血清ACL、RF的影响  

Clinical Effect Observation of Tripterygium Glycosides Combined with Total Glucosides of Paeonia in Treatment of Sjogren’s Syndrome and The Influence on Serum ACL and RF

作　　者：干敏芝 俞金金 邓媛[3] GAN Minzhi;YU Jinjin;DENG Yuan(University of Chinese Academy of Sciences,Ningbo Huamei Hospital,Ningbo 315010,Zhejiang,China;Institute of Life and Health Industry,Chinese Academy of Sciences,Ningbo 315010,Zhejiang,China;Chinese People’s Liberation Army Joint Logistic Support Force 906 Hospital,Ningbo 315040,Zhejiang,China)

机构地区：[1]中国科学院大学宁波华美医院,浙江宁波315010 [2]中国科学院大学宁波生命与健康产业研究院,浙江宁波315010 [3]中国人民解放军联勤保障部队第906医院,浙江宁波315040

出　　处：《中华中医药学刊》2022年第2期94-96,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2018ZX9926)。

摘　　要：目的研究雷公藤多苷联合白芍总苷治疗干燥综合征的临床效果及对抗心磷脂抗体(ACL)、类风湿因子(RF)的影响。方法选取2018年5月—2020年4月医院诊治的干燥综合征患者114例作为研究对象,按照随机数字表法均分为两组,对照组57例给予白芍总苷治疗,观察组57例给予雷公藤多苷联合白芍总苷治疗,比较两组的临床效果、中医症状积分、ACL及RF水平、不良反应情况。结果观察组、对照组总有效率分别为98.2%(56/57)、86.0%(49/57),观察组显著高于对照组,差异有统计学意义(P<0.05)。两组治疗前各项中医症状积分差异均无统计学意义(P>0.05),治疗后两组的各项中医症状积分均显著降低(P<0.05),并且观察组口咽干燥、舌苔厚腻、皮肤干燥的症状积分显著低于对照组(P<0.05)。治疗前两组血清ACL、RF水平差异均无统计学意义(P>0.05),治疗后两组血清ACL、RF水平均显著降低(P<0.05),并且观察组血清ACL、RF水平显著低于对照组(P<0.05)。观察组、对照组不良反应发生率分别为8.8%(7/57)、7.0%(4/57),组间比较差异无统计学意义(P>0.05)。结论雷公藤多苷联合白芍总苷治疗干燥综合征的临床效果满意,能够显著降低患者的中医症状积分以及血清ACL、RF水平,并且用药安全性可靠,可以作为优选的用药方案。Objective To study the clinical effect of tripterygium glycosides combined with total glucosides of paeonia in the treatment of Sjogren’s syndrome and the influence on anticardiolipin antibodies(ACL)and rheumatoid factor(RF).Methods A total of 114 patients with Sjogren’s syndrome diagnosed and treated in our hospital from May 2018 to April 2020 were selected as the research objects,and they were divided into two groups according to the random number table method.Fifty-seven cases in the control group were given total glucosides of paeonia,and the other 57 cases in the observation group were given tripterygium glycosides combined with total glucosides of paeonia.The clinical effects,TCM symptom scores,levels of ACL and RF and adverse reactions of two groups were compared.Results The total effective rates of the observation group and the control group were 98.2%(56/57)and 86.0%(49/57),respectively.The effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in TCM symptom scores between two groups before treatment(P>0.05).After treatment,the TCM symptom scores in the two groups were significantly reduced(P<0.05),and the TCM symptom scores of dry oropharynx,thick greasy tongue and dry skin in the observation group were significantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference in levels of ACL or RF in serum between two groups(P>0.05).After treatment,the levels of ACL or RF in serum of two groups were significantly reduced(P<0.05),and the levels of ACL or RF in serum in the observation group were significantly lower than those of the control group(P<0.05).The incidences of adverse reactions in the observation group and the control group were 8.8%(5/57)and 7.0%(4/57)respectively,and there was no statistically significant difference between two groups(P>0.05).Conclusion Tripterygium glycosides combined with total glucosides of paeo

关 键 词：干燥综合征 雷公藤多苷 白芍总苷 抗心磷脂抗体 类风湿因子 

分 类 号：R442.8[医药卫生—诊断学]