脑栓通胶囊联合丁苯酞注射液治疗急性脑梗死的疗效及对血流动力学影响  

Effect of Naoshuantong Capsule(脑栓通胶囊)Combined with Butylphthalide Injection on Acute Cerebral Infarction and Its Effect on Hemodynamics

作　　者：薛芳[1] 张永林[1] 张继萍[1] 贾夏艳 XUE Fang;ZHANG Yonglin;ZHANG Jiping;JIA Xiayan(Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)

机构地区：[1]山西医科大学第二医院,山西太原030001

出　　处：《中华中医药学刊》2022年第2期215-218,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：山西省软科学研究一般项目(2017041038-4)。

摘　　要：目的探讨脑栓通胶囊联合丁苯酞注射液治疗急性脑梗死的疗效及对血流动力学影响。方法选取医院收治的急性脑梗死患者122例,随机分为两组各61例,对照组静脉滴注丁苯酞注射液,实验组在对照组基础上口服脑栓通胶囊,两组患者均持续治疗14 d。对比两组患者的临床疗效、美国卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、脑卒中患者生专用活质量量表(Stroke scale quality of life,SS-QOL)评分和巴塞尔指数(Barthel index,)评分、血清全血高切黏度(High shear viscosity,HSV)、血浆黏度(Plasma viscosity,PSV)、血浆纤维蛋白原(Fibrinogen,FIB)水平、血清C-反应蛋白(C-reactive protein,CRP)、细胞因子白介素-6(Interleukin 6,IL-6)及肿瘤坏死因子α(Tumor necrosis factorα,TNF-α)水平、血清谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px),超氧化物歧化酶(Superoxide Dismutase,SOD),一氧化氮(Nitrogen Monoxide,NO)水平及血流动力学指标变化。结果治疗后,实验组总有效率较高(P<0.05);两组治疗前NIHSS评分、SS-QOL评分和Barthel指数评分比较差异无统计学意义(P>0.05);两组治疗后NIHSS评分显著降低,SS-QOL评分和Barthel指数评分明显升高(P<0.05);且实验组改善较明显(P<0.05);两组治疗前血清HSV、PSV和FIB水平比较差异无统计学意义(P>0.05);两组治疗后血清HSV、PSV和FIB水平明显降低(P<0.05),且实验组降低较明显(P<0.05);两组治疗前血清IL-6、TNF-α和CRP水平比较差异无统计学意义(P>0.05);治疗后两组血清IL-6、TNF-α和CRP水平明显降低(P<0.05);且实验组降低较明显(P<0.05);两组治疗前血清SOD、GSH-Px和NO水平比较差异无统计学意义(P>0.05);两组治疗后血清SOD和GSH-Px明显降低,NO水平显著升高(P<0.05),且实验组改善较明显(P<0.05);两组治疗前中动脉收缩期阻力指数(Resistance Index,RI)、血流速度(Diastolic velocity,Vd)、平均血流速度(Mean velocity,Vm)及血流速Objective To investigate the curative effect of Naoshuantong Capsule(脑栓通胶囊)combined with Butylphthalide Injection in the treatment of acute cerebral infarction and its effect on hemodynamics.Methods A total of 122 cases of patients with acute cerebral infarction admitted to our hospital were selected and randomly divided into two groups,61 cases in each group.The control group was intravenously injected with Butylphthalide Injection,and the experimental group was given Naoshuantong Capsule orally on the basis of the control group.Both groups were treated continuously for 14 days.Clinical efficacy,NIHSS score,SS-QOL score,Barthel index score,levels of HSV,PSV and FIB in serum,inflammatory factor levels in serum,levels of SOD,GSH-Px and NO in serum and hemodynamic indexes were compared between two groups.Results After treatment,the total effective rate of the experimental group was higher(P<0.05).NIHSS score,SS-QOL score and Barthel index score had no difference between the two groups before treatment(P>0.05).After treatment,NIHSS score was significantly decreased,while SS-QOL score and Barthel index score were significantly increased(P<0.05).The scores of the experimental group were improved significantly(P<0.05).There were no significant differences in levels of HSV,PSV or FIB in serum between the two groups before treatment(P>0.05).The levels of HSV,PSV and FIB in serum were significantly decreased in both groups after treatment(P<0.05),and significantly decreased in the experimental group(P<0.05).There were no significant differences in serum levels of IL-6,TNF-αor CRP between the two groups before treatment(P>0.05).After treatment,the levels of IL-6,TNF-αand CRP in serum in two groups were significantly decreased(P<0.05).And the levels of the experimental group were decreased significantly(P<0.05).Before treatment,the levels of SOD,GSH-Px and NO in serum were not significantly different between the two groups(P>0.05).After treatment,levels of SOD and GSH-Px in serum of the two groups were significa

关 键 词：脑栓通胶囊 丁苯酞注射液 急性脑梗死 临床疗效 血流动力学 

分 类 号：R277.743.3[医药卫生—中医学]