系统评价芪红通络方治疗气虚血瘀型下肢深静脉血栓后综合征的疗效及其作用机制  

Systematical Evaluation on Efficacy and Mechanism of Qihong Tongluo Decoction(芪红通络方)in Treatment of PTS with Qi Deficiency and Blood Stasis Type

作　　者：楚信强 左敬雅 张婷 马云龙[1] CHU Xinqiang;ZUO Jingya;ZHANG Ting;MA Yunlong(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北省中医院,河北石家庄050000

出　　处：《中华中医药学刊》2022年第2期219-222,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划(2019021)。

摘　　要：目的探讨系统评价芪红通络方治疗气虚血瘀证型下肢深静脉血栓后综合征(PTS)的疗效及其作用机制。方法选自医院于2017年12月—2019年12月收治的PTS患者94例,依据随机数字表法随机分为观察组47例与对照组47例。对照组口服地奥司明片;观察组口服芪红通络方。两组疗程均为12周。比较两组治疗12周总有效率,治疗前与治疗12周主要症状和体征积分、下肢周径差、凝血功能和炎症因子变化,及安全性评价。结果观察组治疗12周总有效率(95.74%,45/47)高于对照组(76.60%,36/47)(P<0.05)。两组治疗12周疼痛、患肢肿胀和皮温升高积分较治疗前降低(P<0.05);观察组治疗12周疼痛、患肢肿胀和皮温升高积分低于对照组(P<0.05)。两组治疗12周膝上周径差和膝下周径差低于治疗前(P<0.05);观察组治疗12周膝上周径差和膝下周径差低于对照组(P<0.05)。两组治疗12周D-二聚体和纤维蛋白原(FIB)较治疗前降低(P<0.05);观察组治疗12周D-二聚体和FIB低于对照组(P<0.05)。两组治疗12周血清TNF-α、IL-6和IL-8水平较治疗前降低(P<0.05);观察组治疗12周血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)水平低于对照组(P<0.05)。两组治疗期间均未出现肝肾功能异常。观察组不良反应(6.38%,3/47)少于对照组(21.28%,10/47)(P<0.05)。结论芪红通络方治疗气虚血瘀型PTS患者疗效良好,其机制可能与改善凝血功能和减轻炎症反应有关,且安全性良好。Objective To systematically evaluate the efficacy and mechanism of Qihong Tongluo Decoction(芪红通络方)in the treatment of deep venous post thrombotic syndrome(PTS)of lower extremity with Qi deficiency and blood stasis type.Methods Ninety-four PTS patients in our hospital from December 2017 to December 2019 were randomly divided into observation group(47 cases)and control group(47 cases).The control group was given Diosmin Tablet and the observation group was given Qihong Tongluo Decoction.The course of treatment was 12 weeks in both groups.The total effective rate,the scores of main symptoms and signs,the circumference difference of lower limbs,the changes of coagulation function and inflammatory factors,and the safety evaluation were compared between the two groups before and after 12 weeks of treatment.Results The effective rate of the observation group(95.74%,45/47)was higher that of the control group(76.60%,36/47)(P<0.05).After 12 weeks of treatment,the scores of pain,limb swelling and skin temperature rise of the two groups were lower than those before treatment(P<0.05).After 12 weeks of treatment,the scores of pain,limb swelling and skin temperature increase in the observation group were lower than those in the control group(P<0.05).After 12 weeks of treatment,the difference of the upper and the lower knee diameter before treatment was significant(P<0.05),while those of the observation group were lower than those of the control group(P<0.05).After 12 weeks of treatment,the D-dimer and FIB of two groups were decreased(P<0.05)and the D-dimer and FIB of the observation group were lower than those of the control group(P<0.05).After 12 weeks of treatment,serum levels of TNF-α,IL-6 and IL-8 of the two groups were lower thsoe before treatment(P<0.05).After 12 weeks of treatment,the serum levels of TNF-α,IL-6 and IL-8 of the observation group were lower than those of the control group(P<0.05).There was no abnormal liver or kidney function in the two groups during the treatment.The adverse reactions in the o

关 键 词：芪红通络方 气虚血瘀证 下肢深静脉血栓后综合征 疗效 作用机制 

分 类 号：R269.544[医药卫生—中西医结合]