血栓心脉宁联合阿托伐他汀钙治疗颈动脉粥样硬化斑块的临床效果  

Clinical Effect of Xueshuan Xinmaining(血栓心脉宁)Combined with Atorvastatin Calcium in Treatment of Carotid Atherosclerotic Plaque

作　　者：李静[1] 彭纪临[1] 张刚 LI Jing;PENG Jilin;ZHANG Gang(Zunyi First People’s Hospital,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义市第一人民医院,贵州遵义563000

出　　处：《中华中医药学刊》2022年第2期255-258,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：贵州省科技厅项目([2020]1Y37);遵义市基金(遵市合HZ字[2019]151)。

摘　　要：目的探讨血栓心脉宁与阿托伐他汀钙口服联合治疗颈动脉粥样硬化斑块患者的效果。方法选取2016年12月—2019年8月医院接诊的颈动脉粥样硬化斑块患者108例。根据患者的就诊日期单日和双日,将其分为人数相等的对照组和观察组,每组均为54例。两组均常规给予药物治疗。对照组给予阿托伐他汀钙口服,观察组给予血栓心脉宁联合阿托伐他汀钙口服。对比两组治疗前后的血脂水平[胆固醇(TC),甘油三酯(TG),低密度脂蛋白(LDL),高密度脂蛋白(HDL)]、血清C反应蛋白水平、颈动脉内膜厚度、斑块面积。对比两组的不良反应情况。结果治疗前,两组的TC、TG、LDL、HDL、血清C反应蛋白、颈动脉内膜厚度、斑块面积数据差异均不具有统计学意义(P>0.05),治疗后,两组的TC、TG、LDL、血清C反应蛋白、颈动脉内膜厚度、斑块面积均降低,HDL均增高(P<0.05)。在治疗后的对比中,观察组的TC、TG、LDL、血清C反应蛋白、颈动脉内膜厚度、斑块面积低于对照组,观察组的HDL高于对照组(P<0.05)。两组各类不良反应的数据差异均不具有统计学意义(P>0.05)。结论对于发生颈动脉粥样硬化斑块的患者,在常规治疗方法的基础上,使用血栓心脉宁联合阿托伐他汀钙口服,有助于缩小斑块,控制血脂水平,降低炎性反应程度,具有良好的安全性。Objective To explore the effect of combined oral administration of Xueshuan Xinmaining(血栓心脉宁)and atorvastatin calcium on patients with carotid atherosclerotic plaque.Methods A total of 108 patients with carotid atherosclerotic plaque admitted to our hospital from December 2017 to August 2019 were divided into a control group and an observation group of equal number according to their visit dates,with 54 cases in each group.Both groups were given routine medication.The control group was given atorvastatin calcium orally,and the observation group was given Xueshuan Xinmaining combined with atorvastatin calcium orally.The blood lipid levels[cholesterol(TC),triglycerides(TG),low density lipoprotein(LDL),high density lipoprotein(HDL)],serum C-reactive protein level,carotid artery intima thickness,plaque area and the adverse reactions of the two groups were compared.Results Before treatment,the differences in TC,TG,LDL,HDL,serum C-reactive protein,carotid artery intimal thickness and plaque area were not statistically significant between the two groups(P>0.05).After treatment,TC,TG,LDL,serum C-reactive protein,carotid artery intima thickness and plaque area were all reduced,and HDL was increased(P<0.05).In the comparison after treatment,the TC,TG,LDL,serum C-reactive protein,carotid artery intima thickness and plaque area of observation group were lower than those of the control group,and the HDL of the observation group was higher than that of the control group(P<0.05).The data difference of various adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion For patients with carotid atherosclerotic plaque,on the basis of conventional treatment,the oral administration of Xueshuan Xinmaining combined with atorvastatin calcium can help to reduce plaques,control blood lipid levels and reduce the degree of inflammatory reactions and has good safety.

关 键 词：血栓心脉宁 阿托伐他汀钙 颈动脉粥样硬化 斑块 血脂 

分 类 号：R259.435[医药卫生—中西医结合]