维生素A联合门冬胰岛素治疗1型糖尿病患儿的效果  

Effects of Vitamin A combined with insulin aspart in treatment of children with type 1diabetes mellitus(T1DM)

作　　者：艾雪 AI Xue(Department of Pediatrics of Huludao Central Hospital,Huludao 125100 Liaoning,China)

机构地区：[1]葫芦岛市中心医院儿科,辽宁葫芦岛125100

出　　处：《中国民康医学》2022年第7期61-64,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察维生素A联合门冬胰岛素治疗1型糖尿病(T1DM)患儿的效果。方法:选取64例T1DM患儿为研究对象,采用随机数字表法将其分为研究组与对照组各32例。对照组采用门冬胰岛素注射液治疗,研究组在对照组基础上联合维生素A治疗,比较两组治疗前后血糖相关指标[空腹血糖、餐后2h血糖、糖化血红蛋白(HbA1c)、血清C-肽]水平、每日胰岛素用量、血清维生素A水平、白细胞介素-17(IL-17)水平、脂蛋白-a(LPa)水平和纤维细胞生长因子-19(FGF19)水平,以及并发症发生率。结果:治疗后,研究组空腹血糖和餐后2h血糖水平均低于对照组,血清C-肽水平高于对照组,差异有统计学意义(P<0.05);研究组每日胰岛素用量低于对照组,差异有统计学意义(P<0.05);治疗后,对照组维生素A水平低于治疗前,研究组维生素A水平高于治疗前,且研究组高于对照组,对照组LPa水平高于治疗前,研究组LPa水平低于治疗前,且研究组低于对照组,研究组IL-17和FGF19水平均低于对照组,差异有统计学意义(P<0.05);研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:维生素A联合门冬胰岛素治疗T1DM患儿可降低空腹血糖水平、餐后2h血糖水平、每日胰岛素用量、LPa水平、IL-17、FGF19水平和并发症发生率,提高血清C-肽水平,其效果优于单纯门冬胰岛素治疗效果。Objective:To observe effects of Vitamin A combined with insulin aspart in treatment of children with type 1 diabetes mellitus(T1DM).Methods:64 children with T1DM were selected as the research objects,and were divided into study group and control group by using the random number table method,32 cases in each group.The control group was treated with insulin aspart injection,while the study group was treated with Vitamin A on the basis of that of the control group.The levels of blood glucose-related indexes[fasting blood glucose,2h postprandial blood glucose,glycosylated hemoglobin(HbA1c),serum C-peptide],the daily insulin dosage,the serum Vitamin A level,the interleukin-17(IL-17)level,the lipoprotein-a(LPa)level,the fibroblast growth factor-19(FGF19)level,and the incidence of complications were compared between the two groups before and after the treatment.Results:After the treatment,the fasting blood glucose level and the 2h postprandial blood glucose level of the study group were lower than those of the control group;the serum C-peptide level was higher than that of the control group;and the differences were statistically significant(P<0.05).The daily insulin dosage of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the vitamin A level in the control group was lower than that before that treatment,the vitamin A level in the study group was higher than that before the treatment,and that of the study group was higher than that of the control group;the LPa level in the control group was higher than that before the treatment,the LPa level in the study group was lower than that before the treatment,and that of the study group was lower than that of the control group;the levels of IL-17 and FGF19 in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).Further,the incidence of complications in the study group was lower than that in the control group,and the difference was

关 键 词：1型糖尿病 患儿 维生素A 血糖 血清C-肽 并发症 

分 类 号：R587.1[医药卫生—内分泌]