鼻炎康片联合克拉霉素治疗慢性鼻-鼻窦炎患者的效果  

Effects of Biyankang tablets combined with Clarithromycin in treatment of chronic rhinosinusitis

作　　者：曾琼芳 ZENG Qiongfang(Otolaryngology Department of Longnan Maternal and Child Health Hospital,Ganzhou 341700 Jiangxi,China)

机构地区：[1]龙南妇幼保健院耳鼻喉科,江西赣州341700

出　　处：《中国民康医学》2022年第7期113-116,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察鼻炎康片联合克拉霉素治疗慢性鼻-鼻窦炎(CRS)患者的效果。方法:选取90例CRS患者为研究对象,按照随机数字表法分为对照组和观察组各45例。对照组给予克拉霉素治疗,观察组在对照组基础上联合鼻炎康片治疗,比较两组临床疗效、治疗前后炎性因子[白细胞介素(IL)-4、IL-6、肿瘤坏死因子-α(TNF-α)]水平、临床症状评分、复发率及不良反应发生率。结果:观察组治疗总有效率为93.33%,高于对照组的75.56%,差异有统计学意义(P<0.05);治疗后,观察组IL-4水平高于对照组,IL-6及TNF-α水平均低于对照组,差异有统计学意义(P<0.05);观察组嗅觉减退、流涕、头痛、鼻塞、面部疼痛等临床症状评分均低于对照组,差异有统计学意义(P<0.05);观察组复发率为2.22%,低于对照组的17.78%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:克拉霉素联合鼻炎康片治疗CRS患者,可提高临床疗效,降低炎性因子指标水平,改善临床症状,降低复发风险,且安全性高,其效果优于单纯克拉霉素治疗。Objective:To observe effects of Biyankang tablets combined with Clarithromycin in treatment of chronic rhinosinusitis(CRS).Methods:90 CRS patients were selected as the research objects,and were divided into control group and observation group according to the random number table method,45 cases in each group.The control group was treated with Clarithromycin,while the observation group was treated with Biyankang tablets on the basis of that of the control group.The clinical effects,the inflammatory factor levels[interleukin(IL)-4,IL-6,tumor necrosis factor-α(TNF-α)],the clinical symptom scores,the recurrence rate and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 93.33%,which was higher than 75.56%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the IL-4 level in the observation group was higher than that in the control group;the levels of IL-6 and TNF-αwere lower than those in the control group;and the differences were statistically significant(P<0.05).The clinical symptom scores of hyposmia,runny nose,headache,nasal congestion,and facial pain in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The recurrence rate in the observation group was 2.22%,which was lower than 17.78%in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Clarithromycin combined with Biyankang tablets in the treatment of the CRS patients can improve the clinical effects,reduce the levels of inflammatory factors,improve the clinical symptoms and reduce the risk of recurrence with high safety.Moreover,it is superior to single Clarithromycin treatment.

关 键 词：慢性鼻-鼻窦炎 克拉霉素 鼻炎康片 炎性因子 复发率 不良反应 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]