老年非霍奇金淋巴瘤化疗后肺损伤临床用药特点的分析  

Analysis of the clinical medication characteristics of chemotherapy-induced lung injury in elderly patients with non Hodgkin’s lymphoma

作　　者：董菲[1] 郑东 张朕豪 王翔宇 万伟[1] 王艳芳[1] 刘维[2] 王继军[1] DONG Fei;ZHENG Dong;ZHANG Zhen-hao;WANG Xiang-yu;WAN Wei;WANG Yan-fang;LIU Wei;WANG Ji-jun(Department of Hematology,Peking University Third Hospital,Beijing 100191,China;Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院血液科,北京100191 [2]北京大学第三医院药剂科,北京100191

出　　处：《中国临床药理学杂志》2022年第7期727-730,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的 探讨老年非霍奇金淋巴瘤化疗后肺损伤临床特点。方法 收集老年非霍奇金淋巴瘤患者化疗后肺损伤25例,对其临床症状、相关检查、化疗方案、治疗效果及预后进行分析。结果 在25例患者中,男13例,女12例;主要症状为发热、咳嗽、呼吸困难、胸闷、咳痰,亦可无症状通过影像学检查发现;电子计算机断层扫描/正电子发射计算机断层显像检查表现为肺部弥漫或多发局灶性磨玻璃影;21例患者使用了含利妥昔单抗的方案;25例患者激素治疗均有效;中位随访12个月,失访3例,13例死亡,肺损伤前原发病状态为独立预后危险因素;9例存活患者生活质量无影响。结论 化疗性肺损伤无特异性临床表现,新型靶向药物不除外导致其发生率增加,老年患者预后差,应尽可能早期发现、早期治疗从而改善临床预后。Objective To investigate the clinical characteristics of chemotherapy-induced lung injury in elderly patients with non-Hodgkin’s lymphoma. Methods Twenty-five elderly patients with chemotherapy-induced lung injury were selected. The clinical symptoms, related examination, chemotherapy regimen, therapeutic effect and prognosis were analyzed. Results Among the 25 patients, 13 were male and 12 were female;the main symptoms were fever, cough, dyspnea, chest tightness, expectoration, and no symptoms were found by imaging examination;computer tomography/positron emission tomography showed diffuse or multiple focal ground glass shadow in the lung;21 patients used rituximab containing regimen;25 patients were effective in corticosteroids therapy;the median follow-up was 12 months, 3 patients lost follow up, and the rest 13 patients were dead. The causes of death were complications of corticosteroids, infection and tumor progression, and the quality of life of 9 surviving patients was not affected. Conclusion There is no specific clinical manifestation of chemotherapy-induced lung injury. The incidence of new targeted drugs is increased, and the prognosis of elderly patients is poor. We should find and treat as early as possible to improve the clinical prognosis.

关 键 词：非霍奇金淋巴瘤 老年患者 化疗 肺损伤 

分 类 号：R97[医药卫生—药品]