以苄醇和亚铁氰化钾为原料的芳腈合成新方法研究  

The Study on a New Method for the Synthesis of Aromatic Nitriles with Benzyl Alcohols and K_(4)[Fe(CN)_(6)]as the Raw Materials

作　　者：吴青 张永江 田欣哲 郑先福[3] WU Qing;ZHANG Yongjiang;TIAN Xinzhe;ZHENG Xianfu(Luoyang Testing Center for Quality and Measurement,Luoyang Henan 471000,China;Luoyang Cigarette Factory of Henan Chinese Tobacco Industry Corporation Limited,Luoyang Henan 471000,China;College of Science,Henan Agricultural University,Zhengzhou Henan 450002,China)

机构地区：[1]洛阳市质量计量检测中心,河南洛阳471000 [2]河南中烟工业有限责任公司洛阳卷烟厂,河南洛阳471003 [3]河南农业大学理学院,河南郑州450002

出　　处：《江西师范大学学报（自然科学版）》2022年第1期87-92,共6页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：国家自然科学基金(21603060);河南省自然科学基金(212300410358);河南省科技攻关课题(212102310372)资助项目.

摘　　要：该文以Cu_(2)O为催化剂,实现了苄醇与亚铁氰化钾的新反应,为芳腈的合成提供了一种经济有效的新方法.该方法优化了溶剂、催化剂、温度、氧气压强等反应条件,并在最佳反应条件下合成了16个芳腈化合物,分离产率为62%~87%.该文提出了该反应的机理:苄醇首先发生需氧氧化脱氢生成芳基甲醛,然后转化为芳腈.与文献报道的方法相比,该方法使用的反应物苄醇价格更便宜,且Cu_(2)O为多相催化剂,重复使用性能良好,降低了反应成本.The new economic and effective method for the synthesis of aromatic nitriles is found via the realization of a new reaction between benzyl alcohols with K_(4)[Fe(CN)_(6)]using Cu_(2)O as the catalyst.The reaction conditions such as solvent,catalyst,temperature and oxygen pressure are optimized,and sixteen aromatic nitriles are synthesized under the optimum reaction conditions,in which the isolated yields are 62%—87%.The reaction mechanism is proposed that Benzyl alcohols undergo the aerobic oxidative dehydrogenation,followed by the conversion of aryl formaldehyde into aryl nitriles.Compared with the related methods,the substrates are replaced by cheaper benzyl alcohols.Moreover,the used catalyst Cu_(2)O is a heterogeneous catalyst that can be recycled,which obviously decreases the reaction cost.

关 键 词：苄醇 亚铁氰化钾 氧化亚铜 芳腈 

分 类 号：O621[理学—有机化学]