卵巢子宫内膜异位囊肿组织中Bax、Bcl-2蛋白表达与超声引导下聚桂醇介入术后复发的关系分析  

Expressions of Bax and Bcl-2 proteins in ovarian endometriosis cysts and their relationships with recurrence after ultrasound-guided lauromacrogol intervention

作　　者：张云华 范志青 ZHANG Yunhua;FAN Zhiqing(Department of Ultrasoud,Beijing Nuclear Industry Hospital,Beijing 100045,China;Nursing Department,Beijing Nuclear Industry Hospital,Beijing 100045,China)

机构地区：[1]北京核工业医院超声科,北京100045 [2]北京核工业医院护理部,北京100045

出　　处：《现代医学》2022年第1期47-52,共6页Modern Medical Journal

摘　　要：目的:观察卵巢子宫内膜异位囊肿组织中B淋巴细胞瘤-2相关X(Bax)、B淋巴细胞瘤-2(Bcl-2)蛋白表达,并分析其与超声引导下聚桂醇介入术后复发的关系。方法:回顾性分析221例卵巢子宫内膜异位囊肿实施超声引导下聚桂醇介入术治疗的患者的资料,术中均取囊肿组织,记为研究组;另回顾性分析206例良性病变患者的资料,均经活检穿刺术取卵巢子宫内膜组织并有石蜡存档标本,记为对照组。采用免疫组化法检测2组组织中Bax、Bcl-2蛋白表达;对研究组随访3年,对比复发和未复发患者囊肿组织Bax、Bcl-2蛋白阳性表达率;采用Logistic多元回归分析探讨Bax、Bcl-2蛋白表达与研究组复发的关系。结果:研究组增生期、分泌期Bax蛋白阳性表达率及总阳性表达率均低于对照组,Bcl-2蛋白阳性表达率均高于对照组,差异均有统计学意义(P<0.05);研究组复发率为22.17%,复发患者囊壁厚度≥0.3 cm,入院时血清CA125阳性,Bax蛋白阴性表达率、Bcl-2蛋白阳性表达率均高于未复发患者,差异均有统计学意义(P<0.05),且Logistic多元回归分析证实以上变量均为研究组复发的独立危险因素。结论:在卵巢子宫内膜异位囊肿组织中Bax蛋白阳性表达率低,Bcl-2蛋白阳性表达率高,且Bax蛋白阴性表达、Bcl-2蛋白阳性表达与囊壁厚度≥0.3 cm和入院时血清CA125阳性等均可增加超声引导下聚桂醇介入术后复发的风险。Objective:To observe the expressions of B-lymphoma-2-related X(Bax)and B-lymphoma-2(Bcl-2)proteins in ovarian endometriosis cysts,and to analyze their relationships with the recurrence after ultrasound guided lauromacrogol intervention.Methods:The data of 221 cases of ovarian endometriosis cyst treated by ultrasound guided lauromacrogol intervention were retrospectively analyzed.In addition,the data of 206 patients with benign lesions were retrospectively analyzed.The ovarian endometrial tissues were obtained by biopsy and the paraffin embedded specimens were recorded as the control group.The expressions of Bax and Bcl-2 proteins were detected by immunohistochemistry.The study group was followed up for 3 years to compare the positive expression rates of Bax and Bcl-2 proteins between recurrent and non recurrent cysts.The relationships between the expressions of Bax and Bcl-2 proteins and the recurrence of the study group were analyzed by Logistic multiple regression analysis.Results:The positive expression rates of Bax protein in proliferative and secretory phase and total positive expression rate of study group were lower than those of control group,and the positive expression rates of Bcl-2 protein were higher than those of control group with statistically significant differences(P<0.05).The recurrence rate of the study group was 22.17%.The proportions of recurrent patients with cyst wall thickness≥0.3 cm,serum CA125 positive,negative expression rate of Bax protein and positive expression rate of Bcl-2 protein were higher in patients with recurrence than those without recurrence with statistically significant differences(P<0.05).Logistic multiple regression analysis confirmed that the above variables were independent risk factors for recurrence in the study group.Conclusion:Low positive rate of Bax protein and high Bcl-2 positive expression in ovarian endometriosis cyst tissue,and negative Bax expression plus positive Bcl-2 protein and with cyst wall≥0.3 cm,and positive serum CA125 at admission can increase

关 键 词：B淋巴细胞瘤-2相关X蛋白 B淋巴细胞瘤-2蛋白 卵巢子宫内膜异位囊肿 超声引导下聚桂醇介入术 复发 

分 类 号：R711.75[医药卫生—妇产科学]