涤痰汤治疗痰瘀互结型阻塞性睡眠呼吸暂停综合征疗效观察及对还原型谷胱甘肽、丙二醛水平的影响  

Observation of Ditan Tang for Obstructive Sleep Apnea-Hypopnea Syndrome of Binding of Phlegm and Stasis Type and Its Effect on Reduced Glutathione and Malondialdehyde

作　　者：徐小小 刘刚[1] 郑陈月 XU Xiaoxiao;LIU Gang;ZHENG Chenyue

机构地区：[1]温州市中医院呼吸与危重症医学科,浙江温州325000

出　　处：《新中医》2022年第6期34-38,共5页New Chinese Medicine

基　　金：浙江省温州市科技局公益性社会发展(医疗卫生)科技项目(Y20170297)。

摘　　要：目的:观察涤痰汤治疗痰瘀互结型阻塞性睡眠呼吸暂停综合征(OSAHS)的临床疗效及其对血清还原型谷胱甘肽(GSH)、丙二醛(MDA)水平的影响。方法:选取60例OSAHS患者作为研究对象,以简单随机化法分为对照组和试验组各30例。对照组给予单纯基础治疗,试验组在对照组的基础上加用涤痰汤治疗。治疗8周后评估2组临床疗效,并于治疗前后进行多导眠睡图监测、氧化应激标志物水平检测及安全性评估。结果:试验组总有效率为83.30%,高于对照组的10.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组氧减指数(ODI)、呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(LSaO_(2))比较,差异无统计学意义(P>0.05)。治疗4、8周,试验组AHI、ODI水平较治疗前降低(P<0.05),LSaO_(2)水平较治疗前升高(P<0.05);且试验组AHI、ODI水平低于对照组(P<0.05),LSaO_(2)水平高于对照组(P<0.05);对照组LSaO_(2)、AHI、ODI水平治疗前后组内比较,差异无统计学意义(P>0.05)。治疗前,2组MDA、GSH水平比较,差异无统计学意义(P>0.05)。治疗4、8周,试验组MDA水平较治疗前降低(P<0.05),GSH水平较治疗前升高(P<0.05);且试验组MDA水平低于对照组(P<0.05),GSH水平高于对照组(P<0.05)。对照组MDA、GSH水平治疗前后比较,差异无统计学意义(P>0.05)。治疗期间,2组均未出现严重不良反应。结论:涤痰汤治疗痰瘀互结型OSAHS患者疗效肯定,有利于改善患者睡眠情况,改善氧化应激反应,且无明显不良反应。Objective:To observe the clinical effect of Ditan tang on obstructive sleep apnea-hypopnea syndrome(OSAHS) of bingding of phlegm and stasis type and its effect on serum reduced glutathione(GSH) and malondialdehyde(MDA).Methods:A total of 60 patients with OSAHS were selected and divided into the control group and the experiment group according to the simple randomization method,with 30 cases in each group.The control group was treated with basic treatment only,and the experiment group was additionally treated with Ditan tang based on the treatment of the control group.After eight weeks of treatment,the clinical effects in the two groups were evaluated,and polysomnography monitoring,detection of levelsof oxidative stress markers and safety assessment were performed before and after treatment.Results:The total effective rate was 83.30%in the experiment group,higher than that of 10.00%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of oxygen desaturation index(ODI),apnea-hypopnea index(AHI) and the lowest blood oxygen saturation(LSaO_(2))at night in the two groups(P>0.05).After four and eight weeks of treatment,the levels of AHI and ODI in the experiment group were decreased when compared with those before treatment(P<0.05),the level of LSaO_(2)was increased(P<0.05);the levels of AHI and ODI in the experiment group were lower than those in the control group(P<0.05),the level of LSaO_(2)was higher;there was no significant difference being found in the comparison of levels of LSaO_(2),AHI and ODI in the contro group before and after treatment(P>0.05).Before treatment,there was no significant difference being found in the comparison of levels of MDA and GSH between the two groups(P>0.05).After four and eight weeks of treatment,the leve of MDA in the experiment group was decreased when compared with that before treatment(P<0.05),and the level of GSH was increased(P<0.05);the level of MDA in the experiment group was lower than

关 键 词：阻塞性睡眠呼吸暂停综合征 涤痰汤 痰瘀互结型 丙二醛 还原型谷胱甘肽 

分 类 号：R563.8[医药卫生—呼吸系统]