二黄解毒汤联合氢化可的松治疗热结肠腑型脓毒症胃肠功能障碍临床研究  

Clinical Study on Erhuang Jiedu Tang Combined with Hydrocortisone for Sepsis Complicated with Gastrointestinal Dysfunction of Heat Accumulation in the Intestine Type

作　　者：胡赛 何晓燕[2] 吴宏华[3] HU Sai;HE Xiaoyan;WU Honghua

机构地区：[1]常山县人民医院中药房,浙江常山324200 [2]常山县人民医院中医科,浙江常山324200 [3]衢州市人民医院中药房,浙江衢州324000

出　　处：《新中医》2022年第6期102-105,共4页New Chinese Medicine

摘　　要：目的:观察二黄解毒汤联合氢化可的松治疗热结肠腑型脓毒症胃肠功能障碍的临床疗效。方法:选取脓毒症患者66例,按随机数字表法分为对照组和观察组各33例。2组给予西医常规治疗,对照组予氢化可的松治疗,观察组在对照组的基础上给予二黄解毒汤治疗。2组疗程均为1周。比较2组胃肠功能障碍评分、腹腔压力、急性生理和慢性健康状况(APACHEⅡ)和马歇尔(Marshall)评分,以及血清超敏C-反应蛋白(hs-CRP)和降钙素原(PCT)水平。结果:治疗后,2组胃肠功能障碍评分、腹腔压力均较治疗前明显降低(P<0.01),且观察组胃肠功能障碍评分、腹腔压力显著低于对照组(P<0.01)。治疗后,2组APACHEⅡ、Marshall评分均较治疗前明显降低(P<0.01),且观察组APACHEⅡ、Marshall评分明显低于对照组(P<0.01)。治疗后,2组血清hs-CRP、PCT水平均较治疗前明显降低(P<0.01),且观察组以上2项指标均明显低于对照组(P<0.01)。结论:在常规治疗的基础上,二黄解毒汤联合氢化可的松治疗热结肠腑型脓毒症胃肠功能障碍,可抑制炎症反应,有效改善患者的胃肠功能,缓解其临床症状。Objective:To observe the clinical effect of the therapy of Erhuang Jiedu tang combined with hydrocortisone on the treatment of sepsis complicated with gastrointestinal dysfunction of heat accumulation in the intestine type. Methods:A total of 66 patients with sepsis were selected and divided into the control group and the observation group according to random number table method, with 33 cases in each group. The two groups received treatment of conventional western medicine. The control group was treated with hydrocortisone;the observation group was additionally treated with Erhuang Jiedu tang based on the treatment of control group. The treatment course of both groups was one week. The scores of gastrointestinal dysfunction, abdominal pressure, scores of acute physiological and chronic health status(APACHE Ⅱ) and Marshall,and levels of serum hypersensitive C-reactive protein(hS-CRP) and procalcitonin(PCT) were compared between the two groups. Results:After treatment,the scores of gastrointestinal dysfunction and abdominal pressure in both groups were significantly decreased when compared with those before treatment(P<0.01), and the scores of gastrointestinal dysfunction and abdominal pressure in the observation group were significantly lower than those in the control group(P<0.01).After treatment,the scores of APACHEⅡ and Marshall in both groups were significantly decreased when compared with those before treatment(P<0.01),and the above two scores in the observation group were significantly lower than those in the control group(P<0.01). After treatment, the levels of serum h S-CRP and PCT in both groups were decreased when compared with those before treatment(P<0.01), and the above two indexes in the observation group were significantly lower than those in the control group(P<0.01). Conclusion: Based on the conventional treatment, the application of Erhuang Jiedu tang combined with hydrocortisone sepsis complicated with gastrointestinal dysfunction of heat accumulation in the intestine syndrome can inhibit i

关 键 词：脓毒症 热结肠腑证 二黄解毒汤 氢化可的松 胃肠功能 炎症因子 

分 类 号：R631[医药卫生—外科学]