消炎利胆片联合诺氟沙星胶囊治疗慢性胆囊炎的临床效果及安全性  

Clinical efficacy and safety of Xiaoyan Lidan tablets combined with norfloxacin capsules in the treatment of chronic cholecystitis

作　　者：车钰 王伟[1] CHE Yu;WANG Wei(Hepatobiliary Surgery Department,Tongchuan Mining Bureau Central Hospital Affiliated to Shaanxi University of Chinese Medicine,Tongchuan 727000,China)

机构地区：[1]陕西中医药大学附属铜川矿务局中心医院肝胆外科,陕西铜川727000

出　　处：《临床医学研究与实践》2022年第13期106-109,共4页Clinical Research and Practice

摘　　要：目的 探讨消炎利胆片联合诺氟沙星胶囊治疗慢性胆囊炎的临床效果及安全性。方法 选择2019年1月至2019年12月在我院肝胆外科进行慢性胆囊炎治疗的122例患者为研究对象,采用随机数字法将其分为对照组和研究组,每组61例。对照组采取诺氟沙星胶囊治疗,研究组采取消炎利胆片联合诺氟沙星胶囊进行治疗。治疗14 d后,比较两组患者的临床疗效、临床证候(恶心呕吐、纳呆腹胀、小便赤黄)积分及肝胆功能指标(AST、ALT)、血清生化指标(总胆固醇、胆红素、总胆汁酸)、炎性因子(hs-CRP、TNF-α)水平、不良反应发生情况。结果 研究组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗14 d后,研究组的恶心呕吐、纳呆腹胀、小便赤黄及整体证候积分均低于对照组(P<0.05)。治疗14 d后,研究组患者的肝胆功能指标(AST、ALT)、血清炎性因子(hs-CRP、TNF-α)水平均显著低于对照组(P<0.05)。治疗14 d后,研究组的总胆固醇水平显著低于对照组,差异具有统计学意义(P<0.05);而两组的胆红素、总胆汁酸水平比较,差异无统计学意义(P>0.05)。研究组的不良反应总发生率显著低于对照组,差异具有统计学意义(P<0.05)。结论 消炎利胆片联合诺氟沙星胶囊治疗慢性胆囊炎的临床效果显著,可降低临床证候积分,改善肝胆功能、炎性因子,且安全性高,值得在临床上推广应用。Objective To investigate the clinical efficacy and safety of Xiaoyan Lidan tablets combined with norfloxacin capsules in the treatment of chronic cholecystitis.Methods One hundred and twenty-two patients with chronic cholecystitis treated in hepatobiliary surgery department of our hospital from January to December in 2019 were selected as the research objects.The patients were divided into control group and study group by random number method,with 61cases in each group.The control group was treated with norfloxacin capsules,and the study group was treated with Xiaoyan Lidan tablets combined with norfloxacin capsules.After 14 d of treatment,the clinical efficacy,clinical syndrome(nausea and vomiting,abdominal distension,red and yellow urine) scores,hepatobiliary function indexes(AST,ALT),serum biochemical indexes(total cholesterol,bilirubin,total bile acid),inflammatory factors indexes(hs-CRP,TNF-α)levels and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was significantly higher than that in the control group,and the difference was statistically significant(P <0.05).After 14 d of treatment,the scores of nausea and vomiting,abdominal distension,red and yellow urine and overall symptom in the study group were lower than those in the control group(P<0.05).After 14 d of treatment,hepatobiliary function indexes(AST and ALT),serum inflammatory factors indexes(hs-CRP,TNF-α) levels in the study group were significantly lower than those in the control group(P<0.05).After 14 d of treatment,the total cholesterol level in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05);but there were no significant differences in the levels of bilirubin and total bile acid between the two groups(P>0.05).The total incidence of adverse reactions in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05)

关 键 词：慢性胆囊炎 消炎利胆片 诺氟沙星 炎性因子 

分 类 号：R256.43[医药卫生—中医内科学]