短期口服抗生素对伴白细胞精子症畸形精子不育患者的治疗效果  

Effect of short-term oral antibiotics on the treatment of teratozoospermia with leukocytospermia

作　　者：胡雷 王俊豪 巢杏慧[3] 陈栋[4] HU Lei;WANG Junhao;CHAO Xinghui;CHEN Dong(Department of Andrology,Hospital for Reproductive Medicine of Guangdong,Guangzhou 510600,Guangdong,China;Reproductive Medicine Center,the Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 510330,Guangdong,China;Department of Urology,the First Affiliated Hospital of Jinan University,Guangzhou 510660,Guangdong,China;Department of New Medicine,the First Affiliated Hospital of Jinan University,Guangzhou 510660,Guangdong,China)

机构地区：[1]广东省生殖医院男科,广州510600 [2]中山大学附属第七医院生殖中心,广东深圳510330 [3]暨南大学附属第一医院泌尿外科,广州510660 [4]暨南大学附属第一医院新医科,广州510660

出　　处：《中国性科学》2022年第4期14-18,共5页Chinese Journal of Human Sexuality

基　　金：广东省医学科研基金(B2022265)。

摘　　要：目的探讨抗氧化剂治疗伴白细胞精子症畸形精子不育患者时,给予抗生素治疗生殖系统感染对精液参数的影响。方法选取2017年5月至2020年11月于暨南大学附属第一医院就诊的149例伴白细胞精子症的畸形精子不育患者作为研究对象,将给予抗氧化剂治疗的48例患者纳入对照组,将给予抗生素+抗氧化剂治疗后白细胞精子症治愈的59例患者纳入治疗1组,将给予抗生素+抗氧化剂治疗后仍存在白细胞精子症的42例患者纳入治疗2组。比较三组治疗前后精液参数及组间精液改善情况。结果三组治疗后pH、活率、前向运动精子率(PR)、正常精子率都较治疗前有显著升高(P<0.05),精浆白细胞过氧化物酶显著下降(P<0.05);对照组精子密度较治疗前显著升高(P<0.05),治疗1组精子密度、顶体酶、精浆锌均较治疗前显著升高(P<0.05);治疗1组pH、活率、PR、顶体酶活性、精浆白细胞过氧化物酶改善均优于治疗2组和对照组(P<0.05),治疗2组正常精子率改善差于治疗1组和对照组(P<0.05)。结论对伴白细胞精子症畸形精子不育患者可先给予短期抗生素口服治疗,治愈白细胞精子症可使抗氧化剂治疗畸形精子有更好的效果。Objective To investigate the effect of antibiotics on semen parameters in the treatment of infertility with leucospermia with anti-oxidants.Methods 149 male patients with teratozoospermia accompanied by leukocytospermia treated in the First Affiliated Hospital of Jinan University from May 2017 to November 2020 were retrospectively analyzed,among which 48 cases treated with antioxidants as the control group,59 cases with leukocytospermia cured after treatment with antibiotics and antioxidants as the treatment group 1,and 42 cases with leukocytospermia still existed after treatment with antibiotics and antioxidants as the treatment group 2.The semen parameters of the three groups before and after treatment were compared,and the semen improvement of the three groups after treatment was also compared.Results After treatment,the pH,motility rate,PR and normal sperm rate of the three groups were significantly higher than those before treatment(P<0.05),and the leukocyte peroxidase in seminal plasma of the three groups decreased significantly after treatment(P<0.05).The sperm density of the control group was significantly higher than that before treatment(P<0.05),and the sperm density,acrosin and seminal plasma zinc of the treatment group 1 were significantly higher than those before treatment(P<0.05).The treatment group 1 was superior to the treatment group 2 and the control group in the improvement of pH,motility rate,PR,acrosin activity and leukocyte peroxidase in seminal plasma(P<0.05),and the treatment group 2 was inferior to the treatment group 1 and the control group in the improvement of normal sperm rate(P<0.05).Conclusions For male with teratozoospermia accompanied by leukocytospermia,short-term oral antibiotic therapy should be firstly considered.Curing leukocytospermia has better efficacy on teratozoospermia treated by antioxidants.

关 键 词：白细胞精子症 畸形精子症 抗生素 抗氧化剂 精液参数 

分 类 号：R697[医药卫生—泌尿科学]