针刺改善缺血再灌注心肌铁死亡的研究现状与展望  

Research status and Prospect of acupuncture in improving the ferroptosis of myocardial after ischemia-reperfusion

作　　者：李思静 刘彩娇 任玉兰[1] LI Si-jing;LIU Cai-jiao;REN Yu-lan(College of Acupuncture-Moxibustion and Tuina,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610075)

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075

出　　处：《按摩与康复医学》2022年第11期54-57,共4页Chinese Manipulation and Rehabilitation Medicine

基　　金：国家自然科学基金委员会面上项目(81873239):基于NLRP3泛素化-苏素化调控通路研究针刺防治心肌缺血再灌注损伤的抗细胞焦亡作用及机制,负责人:任玉兰。

摘　　要：铁死亡是一种依赖于铁,因细胞活性氧和脂质过氧化物异常堆积致使氧化还原平衡失调引起的细胞程序性死亡。铁死亡的发生主要与铁代谢、脂质过氧化、谷胱甘肽和氨基酸的代谢等多条途径有关。研究发现铁死亡存在于心肌缺血再灌注过程中,抑制铁死亡的发生可以减轻心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)。针刺可有效改善MIRI,现有研究已经表明针刺参与调控铁死亡通路上多个关键靶点。故文章通过探讨铁死亡的主要作用机制及其与MIRI的关系,从铁死亡的角度探讨针刺改善MIRI的可能作用机制及未来研究方向。Ferroptosis is an iron-dependent programmed cell death caused by abnormal accumulation of cellular reactive oxygen species and lipd peroxides,resulting in imbalance of redox balance.Ferroptosis is mainly related to iron metabolism,lipid peroxidation,glutathione and amino acid metabolism.Studies have found that iron death exists in the process of myocardial ischemia-reperfusion.Inhibiting the occurrence of ferroptosis can effectively reduce myocardial ischemia-reperfusion injury(MIRI).Acupuncture can effectively improve MIRI.Existing studies have shown that acupuncture is involved in regulating multiple key targets in the pathway of ferroptosis.Therefore,this paper discusses the possible mechanism and future research direction of acupuncture improving MIRI from the perspective of ferroptosis by discussing the main mechanism of ferroptosis and its relationship with MIRI.

关 键 词：针刺 心肌缺血再灌注 铁死亡 综述 

分 类 号：R245[医药卫生—针灸推拿学]