New concepts for generating interspecies chimeras using human pluripotent stem cells  

作　　者：Alejandro De Los Angeles Jun Wu 

机构地区：[1]Department of Psychiatry,Yale University School of Medicine,New Haven,CT,USA [2]Department of Molecular Biology,University of Texas Southwestern Medical Center,Dallas,TX,USA [3]Hamon Center for Regenerative Science and Medicine,University of Texas Southwestern Medical Center,Dallas,TX,USA

出　　处：《Protein & Cell》2022年第4期234-238,共5页蛋白质与细胞（英文版）

摘　　要：The worldwide paucity of transplantable organs for patients is a devastating problem.While different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant attention recently is the prospect of producing human organs in animals through a technique called interspecies blastocyst complementation based on the generation of interspecies chimeras.Interspecies blastocyst complementation works by injecting pluripotent stem(PS)cells from one species into organogenesis-disabled blastocysts of another species(Kobayashi et al.,2010).As the chimeric embryo develops,donor cells can fill the vacated developmental organ niche and enrich in a target organ of interest.In principle,interspecies blastocyst complementation may one day allow the generation of human organs inside animals.However,some ethical issues concerning research and potential human clinical use with chimeras persist(Hyun,2019).

关 键 词：ORGANS DONOR GENERATING 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]