25-(OH)-D_(3)、Hcy、E_(2)在良性阵发性位置性眩晕患者中的水平及临床意义  

Levels and clinical significance of 25-(OH)-D_(3),Hcy and E_(2) in patients with benign paroxysmal positional vertigo

作　　者：连蕾[1] 车勇军[2] 韩海平[1] 冯志星[1] LIAN Lei;CHE Yongjun;HAN Haiping;FENG Zhixing(Department of Otolaryngology,Handan Central Hospital,Handan,Hebei 056001,China;Department of General Surgery,Handan Central Hospital,Handan,Hebei 056001,China)

机构地区：[1]邯郸市中心医院耳鼻喉科,河北邯郸056001 [2]邯郸市中心医院普通外科,河北邯郸056001

出　　处：《国际检验医学杂志》2022年第9期1041-1045,共5页International Journal of Laboratory Medicine

基　　金：河北省医学科学研究课题(20211144)。

摘　　要：目的分析25羟维生素D_(3)[25-(OH)-D_(3)]、同型半胱氨酸(Hcy)、雌二醇(E_(2))在良性阵发性位置性眩晕(BPPV)患者中的水平及临床意义。方法选取该院2019年1月至2021年1月收治的BPPV患者128例作为BPPV组,另外选取在该院体检的健康志愿者75例作为健康组,采用化学发光法测定25-(OH)-D_(3)、E_(2)水平,免疫散射法测定Hcy水平,分析25-(OH)-D_(3)、Hcy、E_(2)在健康组与BPPV组及不同疾病严重程度组的水平。结果与健康组比较,BPPV组25-(OH)-D_(3)、E_(2)水平降低,Hcy水平升高(P<0.05)。受试者工作特征(ROC)曲线结果显示,25-(OH)-D_(3)、Hcy、E_(2)3项联合较单项检测诊断BPPV的ROC曲线下面积更大(P<0.05)。25-(OH)-D_(3)、E_(2)水平降低,Hcy水平升高及过度劳累为BPPV发生的危险因素(P<0.05)。相关性分析结果显示,25-(OH)-D_(3)与Hcy呈负相关(r=-0.527,P=0.001);25-(OH)-D_(3)与E_(2)呈正相关(r=0.530,P=0.001);Hcy与E_(2)呈负相关(r=-0.660,P=0.001)。结论25-(OH)-D_(3)、E_(2)水平在BPPV患者中降低,Hcy水平升高,且与患者疾病严重程度相关,可作为评估患者疾病严重程度的指标。Objective To analyze the levels and clinical significance of 25-hydroxyvitaminD_(3)[25-(OH)-D_(3)],homocysteine(Hcy)and estradiol(E_(2))in patients with benign paroxysmal positional vertigo(BPPV).Methods A total of 128 patients with BPPV admitted to the hospital from January 2019 to January 2021 were selected as the BPPV group,and another 75 healthy volunteers in the hospital were selected as the healthy group.The levels of 25-(OH)-D_(3) and E_(2) were determined by chemiluminescence method,and the level of Hcy was determined by real-time fluorescence quantitative method,and the expression levels of 25-(OH)-D_(3),Hcy and E_(2) in healthy group and BPPV group and the groups of different disease severity.Results Compared with those in the healthy group,the levels of 25-(OH)-D_(3) and E_(2) decreased,and the level of Hcy increased in the BPPV group(P<0.05).Receiver operating characteristic(ROC)curve showed that compared with 25-(OH)-D_(3),Hcy and E_(2) alone,the area under ROC curve of combined detection of three indexes for diagnosis of BPPV was bigger(P<0.05).The decrease of 25-(OH)-D_(3) and E_(2) levels,the increase of Hcy level and overwork were the risk factors of BPPV(P<0.05).The correlation analysis results showed that 25-(OH)-D_(3) negatively correlated with Hcy(r=-0.527,P=0.001),25-(OH)-D_(3) positively correlated with E_(2)(r=0.530,P=0.001),and Hcy negatively correlated with E_(2)(r=-0.660,P=0.001).Conclusion 25-(OH)-D_(3) and E_(2) levels decrease,and Hcy level increases in BPPV,which correlates with the severity of the disease in patients and could be used as indicators to evaluate the severity of the disease in patients.

关 键 词：25-羟基维生素D_(3) 同型半胱氨酸 雌二醇 良性阵发性位置性眩晕 严重程度 

分 类 号：R446.1[医药卫生—诊断学]