造影剂肾病患者尿TIMP-2、IGFBP7水平的相关性及临床意义  

Clinical significance of urinary TIMP-2 and IGFBP7 in early diagnosis of contrast induced nephropathy

作　　者：阿依加肯·卡司木马力 玛伊努尔·阿卜拉 周玮玮 娜孜亚·斯加克 金燕 AYIJIAKEN·Kasimumali;MAYINUER·Abula;ZHOU Weiwei;NAZIYA·Sijiake;JIN Yan(Department of Nephrology,Second People′s Hospital of Kashi Prefecture,Kashi,Xinjiang 844000,China)

机构地区：[1]喀什地区第二人民医院肾病科,新疆喀什844000

出　　处：《国际检验医学杂志》2022年第9期1090-1092,1096,共4页International Journal of Laboratory Medicine

基　　金：新疆维吾尔自治区自然科学基金项目(2018D01C028);喀什地区应用技术研究与开发计划项目(KS2019050)。

摘　　要：目的探究造影剂肾病(CIN)患者尿金属蛋白酶组织抑制剂-2(TIMP-2)、胰岛素样生长因子结合蛋白7(IGFBP7)水平的相关性及临床意义。方法前瞻性收集新疆维吾尔自治区喀什地区第二人民医院住院行造影检查及介入治疗术的182例CIN高危患者的临床资料。根据CIN的定义将患者分为CIN组(91例)和非CIN组(91例)。对比两组患者不同时间点尿液的TIMP-2、IGFBP7水平,分析IMP-2、IGFBP7的相关性,评估TIMP-2、IGFBP7在诊断CIN中的效能。结果CIN组不同时间点尿TIMP-2、IGFBP7水平高于非CIN组,且随着时间的延长逐渐升高,TIMP-2、IGFBP7水平从低到高依次为术前,术后6、12、24 h(P<0.05)。相关性分析结果显示,TIMP-2与IGFBP7呈正相关(r=0.378,P<0.05)。TIMP-2、IGFBP7在诊断CIN中具有较高的效能,且二者联合检测的受试者工作特征曲线下面积(AUC)明显高于单项指标检测(P<0.05)。结论尿TIMP-2、IGFBP7水平与CIN疾病关系密切,尿TIMP-2、IGFBP7水平联合检测可用于早期CIN的诊断,为其临床治疗和预后评估提供参考。Objective To explore the correlation and clinical significance of urinary tissue inhibitor of metalloproteinase-2(TIMP-2)and recombinant insulin like growth factor binding protein 7(IGFBP7)levels in patients with contrast induced nephropathy(CIN).Methods The clinical data of totally 182 high risk patients who had angiography and interventional therapy in Second People′s Hospital of Kashi Prefecture were collected.According to the definition of CIN,patients were divided into CIN group and non CIN group.The levels of TIMP-2 and IGFBP7 in urine of the two groups at different time points were compared,the correlation between IMP-2 and IGFBP7 was analyzed,and the efficacy of TIMP-2 and IGFBP7 in the diagnosis of CIN was evaluated.Results The levels of urinary TIMP-2 and IGFBP7 in CIN group were higher than those in non CIN group at different time points,and gradually increased with the extension of time.The levels of TIMP-2 and IGFBP7 from low to high were preoperative,6,12 and 24 h after operation(P<0.05).The results of correlation analysis showed that TIMP-2 was positively correlated with IGFBP7(r=0.378,P<0.05).TIMP-2 and IGFBP7 had high diagnostic efficiency in the diagnosis of CIN,and the area under curve(AUC)of the combined detection of TIMP-2 and IGFBP7 were significantly higher than those of single detections(P<0.05).Conclusion The levels of urinary TIMP-2 and IGFBP7 are closely related to CIN.The combined detection of urinary TIMP-2 and IGFBP7 could be used for the diagnosis of early CIN and provide reference for its clinical treatment and prognosis evaluation.

关 键 词：金属蛋白酶组织抑制剂-2 胰岛素样生长因子结合蛋白7 造影剂肾病 应用价值 

分 类 号：R446.12[医药卫生—诊断学]