基于氧化应激探讨从痰论治阻塞性睡眠呼吸暂停低通气综合征并发认知功能障碍  

Discussion of traditional Chinese medicine treatment from phlegm in obstructive sleep apnea hypopnea syndrome complicated with cognitive dysfunction based on oxidative stress

作　　者：纪可 刘玲[1,2,3] 王平 黄亮亮[3] JI Ke;LIU Ling;WANG Ping;HUANG Liang-liang(Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,China;Hubei Academy of Traditional Chinese Medicine,Wuhan 430061,China;Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]湖北省中医院,武汉430061 [2]湖北省中医药研究院,武汉430061 [3]湖北中医药大学,武汉430065

出　　处：《中华中医药杂志》2021年第11期6515-6517,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81273648);国家重点研发计划项目(No.2018YFC1705600)。

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是常见的睡眠障碍之一,患者常伴有不同程度的认知功能障碍。氧化应激(OS)在OSAHS并发认知功能障碍的发生发展中起着重要的作用,调节OS水平可能是治疗该病的潜在靶点之一。从中医的视角,痰浊阻滞可能是OSAHS与认知功能障碍共同的发病机制,痰邪的形成演变过程与OS在致病特点上有相似之处。从痰论治可能通过调节OS水平改善OSAHS患者通气功能和认知障碍。Obstructive sleep apnea hypopnea syndrome(OSAHS) is one of the most common sleep disorders. OSAHS patients are often associated with varying degrees of cognitive dysfunction. Oxidative stress(OS) plays an important role in the occurrence and development of OSAHS complicated with cognitive dysfunction. Regulation of oxidative stress may be a potential target for the treatment of the disease. From the perspective of traditional Chinese medicine, stagnation of phlegm is the common pathogenesis of OSAHS and cognitive dysfunction. The formation and evolution of phlegm evil is similar to oxidative stress in terms of pathogenic characteristics. Treatment from phlegm may improve the pulmonary ventilation function and cognitive function of OSAHS patients by regulating the OS level.

关 键 词：氧化应激 阻塞性睡眠呼吸暂停低通气综合征 认知功能障碍 痰邪 

分 类 号：R276.1[医药卫生—中医五官科学] R277.7[医药卫生—中医学]