还原敏感接枝型两亲性聚氨酯的合成及其胶束性能研究  

Synthesis and Micellar Properties of Reduction-sensitive Grafted Amphiphilic Polyurethane

作　　者：陶旺旺 周瑜 刘静怡 陈红祥 赵祖伊 TAO Wangwang;ZHOU Yu;LIU Jingyi;CHEN Hongxiang;ZHAO Zuyi(Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province,School of Chemistry and Chemical Engineering,Wuhan University of Science and Technology,Wuhan 430081,Hubei,China)

机构地区：[1]武汉科技大学化学与化工学院煤转化与新型炭材料湖北省重点实验室,湖北武汉430081

出　　处：《聚氨酯工业》2022年第2期11-14,30,共5页Polyurethane Industry

基　　金：煤转化与新型炭材料湖北省重点实验室基金项目(WKDM201902)。

摘　　要：为提高聚氨酯药物载体的稳定性并实现对药物的控制释放,合成了具有还原敏感性的接枝型两亲性聚氨酯(PUSS-g-m PEG)。采用核磁共振氢谱(;H-NMR)和凝胶渗透色谱(GPC)对所得聚氨酯结构进行了表征。结果表明,PUSS-g-m PEG在水中可自组装形成纳米胶束,其在正常生理条件下具有良好的稳定性;PUSS-g-m PEG胶束对阿霉素(DOX)的载药量为1.9%,具有良好的还原敏感释药性能,可实现对DOX的控制释放。Grafted amphiphilic polyurethane with reduction sensitivity (PUSS-g-m PEG) was synthesized in order to improve the stability of polyurethane drug carriers and realize controlled release of drugs.The structure of the polyurethane was characterized by;H-NMR and GPC.The results showed that PUSS-g-m PEG could self-assemble to form nanomicelles in aqueous solution,which had good stability under normal physiological conditions.The drug load of PUSS-g-m PEG micelles to DOX was 1.9%,which had good reduction-sensitive drug release performance and could achieve controlled release of DOX.

关 键 词：还原敏感性 接枝型 聚氨酯 稳定性 胶束 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业]