四君子汤加减对餐后不适综合征患者外周血线粒体DNA的影响  

Effect of Sijunzi Decoction on mitochondrial DNA in peripheral blood of patients with postprandial discomfort syndrome

作　　者：吕林[1] 王凤云[1] 马祥雪 唐旭东[2] LÜ Lin;WANG Feng-yun;MA Xiang-xue;TANG Xu-dong(Xi Yuan Hospital of China Academy of Chinese Medical Sciences/Beijing Institute of Spleen and Stomach Dis-ease of Traditional Chinese Medicine,Beijing 100091,China;China Academy of Chinese Medical Sciences Beijing 100700,China)

机构地区：[1]中国中医科学院西苑医院脾胃病科/北京市中医脾胃病研究所,北京100091 [2]中国中医科学院,北京100700

出　　处：《时珍国医国药》2022年第3期636-638,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家重点基础研究发展计划(“973”计划)(2013CB531703);国家自然科学基金(81503567,81873297);中国中医科学院优秀青年科技人才培养专项(ZZ13-YQ-006)。

摘　　要：目的探讨四君子汤加减对功能性消化不良(FD)的餐后不适综合征(PDS)亚型患者外周血线粒体DNA的影响。方法70例餐后不适综合征患者随机分为治疗组45例,对照组25例,治疗组分别给予脾虚I号方、II号方、III号方复方颗粒剂,对照组给予含有5%浓度复方颗粒剂安慰剂,两组均是1袋/次,3次/d,治疗4周。观察外周血线粒体拷贝数。结果与治疗前比较,治疗组患者外周血线粒体拷贝数显著增加(P<0.01),对照组患者外周血线粒体拷贝数降低,差异无统计学意义(P>0.05);与对照组比较,治疗组患者外周血线粒体拷贝数显著增加(P<0.05)。结论四君子汤加减治疗PDS的作用机制可能与提高外周血线粒体拷贝数含量有关。Objective To investigate the effect of Sijunzi Decoction on mitochondrial DNA in peripheral blood of patients with functional dyspepsia(FD)and postprandial discomfort syndrome(PDS).Methods 70 patients with postprandial discomfort syn-drome were randomly divided into treatment group(n=45)and control group(n=25).The treatment group was given com-pound granules of spleen deficiency I,II and III,and the control group was given placebo containing 5%concentration of com-pound granules.Both groups were given 1 bag/time,3 times/day for 4 weeks.Results Compared with before treatment,the mitochondrial copy number in the peripheral blood of the treatment group was significantly increased(P<0.01),while that of the control group was decreased(P>0.05);compared with the control group,the mitochondrial copy number of peripheral blood in the treatment group was significantly increased(P<0.05).Conclusion Sijunzi Decoction can strengthen the spleen and promote gastric motility in the treatment of postprandial discomfort syndrome,and the mechanism may be to increase the con-tent of mitochondrial copy number in peripheral blood.

关 键 词：功能性消化不良 餐后不适综合征 四君子汤 线粒体 

分 类 号：R289.5[医药卫生—方剂学] R57[医药卫生—中药学]