参苓白术丸中5种重金属元素的残留检测  

Residue detection of 5 kinds of heavy metal element in Shenling Baizhu pills

作　　者：李正刚 谢秋红[2] 曲涵婷 邵大志[1] 王丹彧 马彧[1] LI Zheng-gang;XIE Qiu-hong;QU Han-ting;SHAO Da-zhi;WANG Dan-yu;MA Yu(Siping Institute for Food and Drug Control,Siping 136000,China;Siping Central People's Hospital,Siping 136000,China;Siping Social Psychiatric Hospital,Siping 136000,China)

机构地区：[1]四平市食品药品检验所,吉林四平136000 [2]四平市中心人民医院,吉林四平136000 [3]四平市社会精神病院,吉林四平136000

出　　处：《中国药物应用与监测》2022年第2期88-91,共4页Chinese Journal of Drug Application and Monitoring

基　　金：吉林省科技发展项目(20210204151YY)。

摘　　要：目的:建立参苓白术丸中铅、砷、汞、镉、铜5种重金属元素的残留检测方法。方法:样品经微波消解后,以锗、铟、铋混合溶液作为内标,采用电感耦合等离子体质谱(ICP-MS)进行5种重金属元素的残留量测定。结果:铅、砷、汞、镉、铜5种重金属元素的线性关系良好(r≥0.9998),回收率在87.4%~106.3%(RSD≤6.1%)范围内,方法的检出限在0.019~0.066 mg·kg^(-1)范围内。7批样品不同程度的检测出了铅、砷、汞、镉、铜,但均在安全限度之内。结论:该检测方法准确,灵敏度高,参苓白术丸中5种重金属元素均达到较好控制。Objective:To establish a method for residue detection of 5 kinds of heavy metal elements including lead(Pb),arsenic(As),mercury(Hg),cadmium(Cd)and copper(Cu)in Shenling Baizhu pills.Methods:The samples were digested by microwave,and then germanium,indium,bismuth mixture solution was used as internal standards for the detection of the residual mass concentration of 5 metal elements by inductively coupled plasma mass spectrometry(ICP-MS).Results:The linear relationship of Pb,As,Hg,Cd and Cu was good(r≥0.9998).The recovery rate was 87.4%-106.3%(RSD≤6.1%).The detection limits of the method ranged was 0.019-0.066 mg·kg^(-1).7 batches of samples contained different concentrations of Pb,As,Hg,Cd and Cu,but all the elements were within safety limits.Conclusion:The method was accurate and sensitive.5 kinds of heavy metal elements were well controlled in Shenling Baizhu pills.

关 键 词：参苓白术丸 微波消解 电感耦合等离子体质谱 重金属元素 

分 类 号：R917[医药卫生—药物分析学] R932[医药卫生—药学]