白族药倒钩刺化学成分研究  

Chemical Constituents of Bai Medicine Rubus Delavayi

作　　者：郝艺 罗晓磊 王敏 张伟 肖朝江 姜北 HAO Yi;LUO Xiaolei;WANG Min;ZHANG Wei;XIAO Chaojiang;JIANG Bei(Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan,Dali 671000,China;College of Pharmacy,Dali University,Dali 671000,China)

机构地区：[1]云南省滇西抗病原植物资源筛选研究重点实验室,云南大理671000 [2]大理大学药学院,云南大理671000

出　　处：《中国民族民间医药》2022年第8期27-30,44,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：大理州科技计划项目(D2019NA02);云南省滇西抗病原植物资源筛选研究重点实验室项目(202105AG070003);国家自然科学基金地区基金项目(81960637);云南省教育厅科学研究基金项目(2021Y400)。

摘　　要：目的:研究白族药用植物倒钩刺干燥全株的化学成分。方法:采用反复硅胶柱色谱以及MCI、D101型大孔树脂、Sephadex LH-20等多种色谱手段对倒钩刺干燥全株95%乙醇提取物进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果:从倒钩刺95%乙醇提取物中分离得到11个化合物,分别鉴定为2α-羟基熊果酸(1)、乌苏酸(2)、2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid(3)、maslinic acid(4)、alphitolic acid(5)、7α-羟基谷甾醇(6)、7β-羟基谷甾醇(7)、没食子酸正丁酯(8)、没食子酸甲酯(9)、龙胆酸(10)、2-呋喃甲酸(11)。结论:化合物1~11均为首次从该植物中分离得到,其中化合物5~8、10、11为首次从悬钩子属中分离得到。Objectives To study the chemical constituentsof Bai medicine Rubus delavayi Franch.Methods The chemical constituents of 95%ethanol extract of R.delavayiwere isolated and purified by repeated silica gel column chromatography,combined with the other column chromatography padded with D101 macroporous resin,MCI,and sephadex LH-20,respectively,and their structures were identified by physicochemical properties and spectral data.Results Eleven compounds were isolated and identified as 2α-hydroxyursolic acid(1),ursolic acid(2),2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid(3),maslinic acid(4),alphitolic acid(5),7α-hydroxysitosterol(6),7β-hydroxysitosterol(7),n-butyl gallate(8),methyl gallate(9),gentisic acid(10),and 2-furoic acid(11).Conclusion All compounds were isolated from R.delavayi for the first time,and compounds 5~8,10,and11werefirstly isolated from genus Rubus.

关 键 词：白族药 三叶悬钩子 蔷薇科 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]