慢性心力衰竭心肌纤维化与胞外信号调节激酶通路研究  

Research overview of myocardial fibrosis and extracellular signal-regulated kinase pathway in chronic heart failure

作　　者：张泽宇 王贤良[1] 侯雅竹[1] 王帅[1] 贾壮壮 毛静远[1] ZHANG Zeyu;WANG Xianliang;HOU Yazhu;WANG Shuai;JIA Zhuangzhuang;MAO Jingyuan(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,P.R.China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381

出　　处：《华西医学》2022年第4期610-614,共5页West China Medical Journal

基　　金：教育部“创新团队发展计划”(IRT-16R54);国家自然科学基金(81904150)。

摘　　要：慢性心力衰竭器质性病变难以逆转的根本原因是心室重构,心肌纤维化是心室重构的病变基础之一,其发展过程涉及复杂的神经-内分泌系统,具体生物学机制尚不明了。既往胞外信号调节激酶通路被认为是治疗肿瘤的经典通路,抑制该通路同样能够延缓心肌纤维化进程从而改善心力衰竭。为此,探究胞外信号调节激酶通路在心肌纤维化中的机制,或为临床拓展慢性心力衰竭防治提供新思路。该文就胞外信号调节激酶通路在心肌纤维化发生发展中的作用机制及其抑制药物进行阐述,以期为基于该通路防治慢性心力衰竭心肌纤维化提供依据。The fundamental reason why the organic lesions of chronic heart failure are difficult to reverse is ventricular remodeling. Myocardial fibrosis(MF) is an important pathological basis of ventricular remodeling. Its development process involves complex biological mechanisms and neuroendocrine system. Extracellular signal-regulated kinase(ERK) pathway is a classic pathway for the treatment of tumors. It is found that the inhibition of the ERK pathway can also slow down the progressive aggravation of MF. Therefore, exploring the mechanism of ERK pathway in MF may provide a new idea for the prevention and treatment of chronic heart failure. In this paper, the mechanism of ERK pathway in the occurrence and development of MF and its inhibition drugs were described, in order to provide evidence for the prevention and treatment of MF in chronic heart failure based on this pathway.

关 键 词：慢性心力衰竭 心肌纤维化 胞外信号调节激酶 

分 类 号：R541.6[医药卫生—心血管疾病]