血清SS、GAS、NO在儿童慢性胃炎中的水平变化及临床意义  

Changes and clinical significance of serum SS,GAS and NO levels in children with chronic gastritis

作　　者：许晓飞 张晓莉 XU Xiaofei;ZHANG Xiaoli(Department of Gastroenterology,Xi'an Daxing Hospital,Xi'an,Shaanxi 710000,China;Department of Pediatric,Qianyang County Traditional Chinese Medicine Hospital,Baoji,Shaanxi 721100,China)

机构地区：[1]西安大兴医院消化内科,陕西西安710000 [2]陕西省宝鸡市千阳县中医医院儿科,陕西宝鸡721100

出　　处：《检验医学与临床》2022年第9期1234-1236,1240,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清生长抑素(SS)、胃泌素(GAS)、一氧化氮(NO)在儿童慢性胃炎中的水平变化及临床意义。方法选择2018年5月至2021年5月于西安大兴医院接受治疗的120例慢性胃炎患儿为研究组,另选取同期接受体检的100例健康儿童为对照组。对比研究组与对照组血清SS、GAS及NO水平。根据慢性胃炎患儿幽门螺杆菌(Hp)检测结果将其分为Hp阳性组(58例)和Hp阴性组(62例),对比两组患儿血清SS、GAS及NO水平;分析慢性胃炎患儿血清SS、GAS及NO水平间的相关性;分析血清SS、GAS及NO对儿童慢性胃炎的诊断效能。结果研究组血清GAS及NO水平较对照组升高,血清SS水平较对照组降低,差异有统计学意义(P<0.05)。Hp阳性组血清GAS及NO水平较Hp阴性组升高,血清SS水平较Hp阴性组降低,差异有统计学意义(P<0.05)。相关性分析结果显示,慢性胃炎患儿血清SS水平与GAS、NO水平均呈负相关(r=-0.8198、-0.9536,P<0.05),血清GAS水平与NO水平呈正相关(r=0.8667,P<0.05)。血清SS、GAS及NO联合检测诊断儿童慢性胃炎的曲线下面积为0.9352(95%CI=0.8256~1.0000,P<0.05)。结论慢性胃炎患儿血清SS、GAS及NO水平与健康儿童存在明显差异。血清SS、GAS及NO水平变化可能与Hp感染有一定关系。血清SS、GAS及NO对儿童慢性胃炎具有较高的诊断价值。Objective To explore the changes and clinical significance of serum somatostatin(SS),gastrin(GAS)and nitric oxide(NO)levels in children with chronic gastritis.Methods A total of 120 children with chronic gastritis who were treated in Xi'an Daxing Hospital from May 2018 to May 2021 were selected as the study group,and 100 healthy children who received physical examination during the same period were selected as the control group.The serum SS,GAS and NO levels were compared between the study group and the control group.According to the Helicobacter pylori(Hp)detection results,children with chronic gastritis were divided into Hp positive group(58 cases)and Hp negative group(62 cases),the serum levels of SS,GAS and NO were compared between the two groups.Analyzed the correlation between serum SS,GAS and NO levels in children with chronic gastritis.The diagnostic efficacy of serum SS,GAS and NO in children with chronic gastritis was analyzed.Results The serum GAS and NO levels in the study group were higher than those in the control group,and the serum SS level was lower than that in the control group,the differences were statistically significant(P<0.05).The serum GAS and NO levels in the Hp positive group were higher than those in the Hp negative group,and the serum SS level was lower than that in the Hp negative group,the differences were statistically significant(P<0.05).The results of correlation analysis showed that serum SS levels were negatively correlated with GAS and NO levels in children with chronic gastritis(r=-0.8198,-0.9536,P<0.05),and serum GAS levels were positively correlated with NO levels(r=0.8667,P<0.05).The area under the curve of combined detection of serum SS,GAS and NO in the diagnosis of chronic gastritis in children was 0.9352(95%CI=0.8256-1.0000,P<0.05).Conclusion The serum levels of SS,GAS and NO in children with chronic gastritis are significantly different from those in healthy children.Serum levels of SS,GAS and NO might be related to Hp infection.Serum SS,GAS and NO have high diagnosti

关 键 词：生长抑素 胃泌素 一氧化氮 慢性胃炎 儿童 

分 类 号：R725.7[医药卫生—儿科]