苯佐卡因合成方法研究进展  

Research progress of the synthetic method of benzocaine

作　　者：寇成[1] 杨晓婧[2] 李楠楠 Kou Cheng;Yang Xiaojing;Li Nannan(Hebei Normal University for Nationalities,Chengde 067000,China;Chengde Medical University,Chengde 067000,China)

机构地区：[1]河北民族师范学院,河北承德067000 [2]承德医学院,河北承德067000

出　　处：《现代盐化工》2022年第2期14-15,共2页Modern Salt and Chemical Industry

基　　金：河北民族师范学院青年基金项目(QN201504)。

摘　　要：目前,国内常用的合成路线是以对硝基甲苯为原料,通过氧化、酯化及还原反应合成苯佐卡因,但工艺路线依然存在污染、低效等问题,因此,查阅了近几年的相关文献,比较了合成路线的优缺点,以寻找一条更适合工业化生产的合成路线。At present,the commonly used synthetic route in China is to synthesize benzocaine from p-nitrotoluene through oxidation,esterification and reduction reactions.However,the process route still has the problems of pollution and inefficiency,therefore,relevant literature in recent years are reviewed and the advantages and disadvantages of synthetic routes are compared,in order to find a synthetic route more suitable for industrial production.

关 键 词：苯佐卡因 合成方法 图解 

分 类 号：TQ460.6[化学工程—制药化工]