Review of construction methods for whole-cell computational models  

作　　者：Jingru Zhou Xingcun Fan Lingfeng Cao Huijie Sun Jianye Xia XueFeng Yan 

机构地区：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China [2]Tianjin Institute of Industrial Biotechnology,Chinese Academy of Science,Tianjin 300308,China [3]Key Laboratory of Smart Manufacturing in Energy Chemical Process,Ministry of Education,East China University of Science and Technology,Shanghai 200237,People’s Republic of China

出　　处：《Systems Microbiology and Biomanufacturing》2022年第2期259-270,共12页系统微生物学与生物制造（英文）

基　　金：This work was fnancially supported by the National Key R&D Program of China(No.2019YFA0904300).

摘　　要：The complex mechanisms of the internal operation of cellular functions have not been fully resolved and these functions are regulated by multiple effects,such as transcription regulation,signal transduction,and enzyme catalysis,forming complex interactive mechanisms.This makes the construction of a whole-cell computational model,containing various complex cellular functions,very challenging.However,biological models have played a significant role in the field of systems biology,such as guiding gene-target mining and studying cell metabolic characteristics.Therefore,there is increasing research interest in the construction of whole-cell computational models.Combining two classical languages of systems biology,this review expounds on the development and challenges of whole-cell computational modeling from the two classical methods of steady-state and dynamic modeling.Finally,we propose a new approach for constructing whole-cell computational models.

关 键 词：Whole-cell computational model Systems biology STEADY-STATE Dynamic modeling 

分 类 号：O17[理学—数学]