多胺的生理功能及其作用机理研究进展  

Research Progress on Physiological Function of Polyamines and Its Mechanism

作　　者：殷运菊 李凤娜[2] 李克克 陈清华[1] YIN Yunju;LI Fengna;LI Keke;CHEN Qinghua(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Hunan Provincial Key Laboratory of Animal Nutrition Physiology and Metabolic Process,Key Laboratory of Agricultural Processes in Subtropical Region,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,China;Henan Golden Lily Biotechnology)

机构地区：[1]湖南农业大学动物科学技术学院,长沙410128 [2]中国科学院亚热带农业生态研究所,中国科学院亚热带农业过程重点实验室,动物营养生理学与代谢过程湖南省重点实验室,长沙410125 [3]河南金百合生物科技股份有限公司,汤阴456150

出　　处：《动物营养学报》2022年第4期2167-2176,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：湖南省“双一流”建设专项(kxk201801004)。

摘　　要：多胺普遍存在于动植物细胞中,广泛参与生物体内的生理和病理过程。动物体内的多胺有3种来源:食物摄入、肠道微生物合成和细胞合成,其中膳食多胺是主要来源。多胺对动物健康有重要影响,作用于肠道成熟和免疫系统的分化和发育方面;此外,多胺的抗氧化和抗炎作用在心血管疾病等慢性疾病的预防中也发挥重要作用。本文主要从多胺调节肠道上皮细胞的迁移、免疫功能、氧化应激状态和心肌细胞凋亡等方面论述多胺的生理功能及其作用机理,同时还对多胺在畜禽生产中的应用进行阐述,以期为多胺在畜禽生产中的应用提供参考。Polyamines commonly exist in animal and plant cells and are widely involved in physiological and pathological processes in organisms.There are three sources of polyamines in animal body:food intake,gut microorganism synthesis and cell synthesis,among which dietary polyamines are the main source.Polyamines have important effects on animal health,including intestinal maturation and differentiation and development of the immune system.In addition,the antioxidant and anti-inflammatory effects of polyamines also play an important role in the prevention of chronic diseases such as cardiovascular disease.In this paper,the physiological function and mechanism of polyamines were discussed from the aspects of the regulation of intestinal epithelial cell migration,immune function,oxidative stress state and myocardial cell apoptosis by polyamines.Meanwhile,the application of polyamines in livestock and poultry production was also described,in order to provide reference for the development and application of polyamines in livestock and poultry feed additives.

关 键 词：多胺 细胞凋亡 肠道 氧化应激 

分 类 号：S816[农业科学—饲料科学]