自噬与炎性牙槽骨的代谢  

Autophagy and inflammation-induced alveolar bone metabolism

作　　者：宋娜 刘官娟 罗姗姗 霍花 程余婷 洪伟[2] 廖健 Song Na;Liu Guanjuan;Luo Shanshan;Huo Hua;Cheng Yuting;Hong Wei;Liao Jian(School of Stomatology/Stomatological Hospital of Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Key Laboratory of Molecular Biology,Guizhou Medical University,Guiyang 550004,Guizhou Province,China)

机构地区：[1]贵州医科大学口腔医学院/附属口腔医院,贵州省贵阳市550004 [2]贵州医科大学分子生物学重点实验室,贵州省贵阳市550004

出　　处：《中国组织工程研究》2022年第32期5217-5222,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(82060207),项目负责人:廖健;贵州省卫生健康委科学技术基金(gzwkj2022-165),项目负责人:廖健。

摘　　要：背景:自噬具有清除受损蛋白质或过多细胞器的作用,能够帮助细胞适应不良环境改变,维持细胞内环境稳定和自我更新,但自噬异常或者功能障碍将导致骨代谢性疾病的发生。目的:综述自噬对炎性牙槽骨代谢的影响。方法:第一作者检索PubMed、Web of Science、Geenmedical、知网、万方等数据库,以“autophagy,osteoblasts,osteoclasts,NLRP3,bone metabolism”为英文检索词,以“自噬,成骨细胞,破骨细胞,NLRP3,骨代谢”为中文检索词,检索2011年1月至2021年11月已发表的所有相关文献,并对其进行了筛选、归纳与分析,最后纳入63篇文献进行综述。结果与结论:①自噬对机体具有保护作用,适度激活自噬有利于维持骨组织内环境稳态,而自噬途径紊乱或异常可能会扰乱骨重建过程中的动态平衡,造成牙槽骨代谢性疾病的发生;②NLRP3炎性小体与自噬具有双向调控作用,自噬可能通过调控NLRP3炎性小体在牙槽骨代谢性疾病的发生发展过程中发挥重要作用。BACKGROUND:Autophagy can remove damaged proteins or excessive organelles,help cells adapt to adverse environmental changes,and maintain intracellular environment stability and self-renewal.However,abnormalities or dysfunctions in autophagy will lead to bone metabolic diseases.OBJECTIVE:To review the effect of autophagy on inflammation-induced alveolar bone metabolism.METHODS:The first author searched PubMed,Web of Science,Geenmedical,WanFang,and CNKI databases for relevant articles published from January 2011 to N ovember 2021.The search terms were "autophagy,osteoblasts,osteoclasts,NLRP3,bone metabolism" in English and Chinese,respectively.Finally,63 articles were included in result analysis after screening,analyzing and summarizing.RESULTS AND CONCLUSION:Autophagy has a protective effect on the body.Moderate activation of autophagy is conducive to maintaining the internal environment homeostasis in bone tissue,and disorder or abnormality of autophagy pathways may disturb the dynamic balance during bone remodeling,res ulting in the occurrence of alveolar bone metabolic diseases.NLRP3 inflammasomes and autophagy have a bidirectional regulatory effect and autophagy may play an important role in the occurrence and development of metabolic diseases in the alveolar bone by regulating NLRP3 inflammasomes.

关 键 词：自噬 破骨细胞 成骨细胞 NLRP3 骨代谢 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]