高强度间歇运动肥胖大鼠鸢尾素、瘦素、脂联素和内脏脂肪的变化  

Changes in irisin,leptin,adiponectin and visceral fat in obese rats undergoing high-intensity intermittent exercise

作　　者：林家煜[1] 黄惠斌[1] 梁波[1] 陈丽君 Lin Jiayu;Huang Huibin;Liang Bo;Chen Lijun(Department of Endocrinology,the Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian Province,China)

机构地区：[1]福建医科大学附属第二医院内分泌科,福建省泉州市362000

出　　处：《中国组织工程研究》2022年第35期5583-5588,共6页Chinese Journal of Tissue Engineering Research

基　　金：福建省中青年教师教育科研项目(JT180197);项目负责人:林家煜。

摘　　要：背景:运动可以诱导肌肉因子的分泌,如鸢尾素(Irisin),它起着调节白色脂肪组织褐变过程的作用,可能有助于肥胖症的治疗。运动介导的褐变效应与运动强度有关,高强度间歇运动在诱导脂肪褐变方面优于中等强度持续训练。目的:观察不同运动干预对肥胖大鼠鸢尾素、瘦素、脂联素和内脏脂肪的影响。方法:50只雄性SPF级SD大鼠分为正常对照组10只及肥胖造模组40只,饲养10周,记录大鼠体质量变化,从造模成功大鼠中挑选体质量较大的30只,分为3组,即肥胖安静对照组、中等强度持续训练组和高强度间歇训练组,每组10只。两个运动组分别进行中等强度持续运动和高强度间歇运动干预,测定不同运动干预对肥胖大鼠体质量、内脏脂肪、血糖、血脂、血鸢尾素、瘦素、脂联素水平的影响。结果与结论:(1)肥胖造模组大鼠较正常对照组大鼠体质量明显增加(P<0.01);高强度间歇训练组终末体质量显著低于中等强度持续训练组(P<0.01);(2)Lee’s指数肥胖安静对照组显著高于正常对照组(P<0.01);高强度间歇训练组明显低于肥胖安静对照组(P<0.01),高强度间歇训练组与正常对照组间无明显差异(P>0.05);(3)肥胖安静对照组脂肪含量显著高于正常对照组(P<0.01),中等强度持续训练组和高强度间歇训练组脂肪含量均显著低于肥胖安静对照组(P<0.01);(4)血清学分析结果显示,肥胖安静对照组空腹血糖显著高于正常对照组(P<0.01);在高脂喂养组中,中等强度持续训练组、高强度间歇训练组血糖显著低于肥胖安静对照组(均P<0.01);(5)肥胖安静对照组三酰甘油、胆固醇和低密度脂蛋白胆固醇水平显著高于正常对照组(均P<0.01);中等强度持续训练组三酰甘油、胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平降低(均P<0.01),高强度间歇训练组三酰甘油(P<0.01)和高密度脂蛋白胆固醇(P<0.05)水平降低;(6)�BACKGROUND:Exercise induces the secretion of muscle factors,such as irisin,which regulates the browning process of white adipose tissue and may contribute to the treatment of obesity.Exe rcise-mediated browning effects are related to exercise intensity and high-intensity intermittent exercise is supe rior to moderate-intensity continuous training in inducing adipose tissue browning.OBJECTIVE:To observe the effects of different exercise interventions on irisin,leptin,adiponectin and visce ral fat in obese rats.METHODS:Fifty male SPF Sprague-Dawley rats were divided into normal control group(n=10)and obese model group(n=40).Changes in body mass were recorded for 10 wee ks.Thirty rats with higher body mass were selected from the successful modeling rats and randomly divided into three groups(n-10 per group):obese quiet control group,obese moderate-intensity continuous exercise group and obese high-intensity intermittent exercise group.The two exercise groups were subjected to moderate-intensity conti nuous exe rcise or high-intensity intermittent exercise.The body mass,visceral fat,blood glucose,blood lipids,blood irisin,leptin and adiponectin levels in the obese rats we re measured after different exercise interventions.RESULTS AND CONCLUSION:(1)The body mass of the rats in the obese model group increased significantly compared with that of the normal control group(P<0.01).The final body mass of the high-intensity intermittent exercise group was significantly lower than that of the moderate-intensity continuous exercise group(P<0.01).(2)The Lee’s index of the obese quiet control group was significantly higher than that of the normal control group(P<0.01)and the Lee’s index of the high-intensity intermittent exercise group was significantly lower than that of the obese quiet control group(P<0.01).However,there was no significant difference between the high-intensity intermittent exercise group and the normal control group(P>0.05).(3)The fat content of the obese quiet control group was significantly higher than t

关 键 词：高强度间歇运动 肥胖 大鼠 Irisin 瘦素 脂联素 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]