伊顿试剂一步法芳环偶联合成联咔唑  

Eaton’s Reagent Assisted One-step Aromatic Coupling Reaction for Preparing Bicarbazoles

作　　者：袁杰 李泽才[2] 曹培 陈润锋 Yuan Jie;Li Zecai;Cao Pei;Chen Runfeng(Nanjing Vocational University of Industry Technology,Jiangsu,210023;Nanjing University of Posts and Telecommunications,Jiangsu,210023)

机构地区：[1]南京工业职业技术大学,江苏210023 [2]南京邮电大学,江苏210023

出　　处：《当代化工研究》2022年第8期97-99,共3页Modern Chemical Research

基　　金：2021年江苏省基础研究计划(自然科学基金)青年项目“窄谱带热活化延迟荧光材料及有机电致发光器件研究”(项目编号:BK20210935);2020年江苏高校自然科学研究面上项目“可见光激发有机长余辉材料的制备及生物应用研究”(项目编号:20KJB140012);2020年南京工业职业技术大学科研启动经费项目“可见光激发有机长余辉材料的制备及生物应用研究”(项目编号:Y20-14-03)。

摘　　要：为实现一步法合成咔唑衍生物二聚体,开发了在温和条件下使用伊顿试剂辅助芳环C(sp^(2))-C(sp^(2))偶联的反应,该反应无需使用反应溶剂和催化剂。通过柱层析和重结晶等方法得到了目标产物单晶,用核磁共振波谱、高分辨质谱和元素分析等测试手段鉴定了化合物结构,用液相色谱法考察了不同当量比和反应条件对产率的影响,当伊顿试剂和原料的摩尔比为1:10,反应时间为12h时,目标产物的产率最高。To prepare bicarbazoles in one step,aromatic C(sp^(2))-C(sp^(2))coupling reaction assisted by Eaton’s reagent without using any solvents and catalysts was investigated under the mild reaction conditions.The pure target material crystal was prepared by chromatographic and recrystallization methods.The structure of bicarbazoles was identified by nuclear magnetic resonance,high resolution mass spectra,elemental analysis and so on.The effects of equivalence ratio and various reaction conditions were studied by liquid chromatograph mass spectrometer analysis.The result showed that the optimum synthesis conditions were as follows:the mole of Eaton’s reagent to substrate was 1:10;the reaction time was 12 hours.

关 键 词：伊顿试剂 偶联反应 二聚体 产率 

分 类 号：TQ203[化学工程—有机化工]