sFRP2在心脏发育和心脏病理改变中作用的研究进展  

RESEARCH PROGRESS ON THE ROLE OF SFRP2 IN CARDIAC DEVELOPMENT AND CARDIAC PATHOLOGICAL CHANGES

作　　者：李海龙 王英男 LI Hailong;WANG Yingnan(Inner Mongolia Medical University,Inner Mongolia,Hohhot 010059)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特市010059 [2]乌兰察布市中心医院,内蒙古乌兰察布市012099 [3]乌兰察布市中心医院老年医学科,012099

出　　处：《内蒙古医科大学学报》2022年第1期92-96,共5页Journal of Inner Mongolia Medical University

摘　　要：分泌型卷曲相关蛋白2(sFRP2)是Wnt信号通路上的一个关键调节分子,在心脏发育过程和心脏病病理学中起着多重调节作用。sFRP2通过双向调节心肌母细胞的扩张和心肌的分化来调节心脏发育,并表现出特殊的时空特异性。在心脏纤维化过程中,sFRP2表现出浓度依赖性,低浓度sFRP2促进心脏纤维化进展,而高浓度的sFRP2抑制心脏纤维化。在病理性心肌肥大改变中,sFRP2对病理性心肌肥大具有保护作用;在血管再生方面,sFRP2可以抑制缺氧引起的内皮细胞凋亡,促进内皮细胞迁移,诱导内皮血管生成,促进血管再生;在心脏再生治疗方面,sFRP2能够改善人间充质干细胞(hMSCs)在氧化应激下的生存能力,提高干细胞移植的治疗效果。笔者就sFRP2在心脏发育及心血管疾病病理改变中的作用进行综述。Secretory curl associated protein 2(SFRP2)is a key regulator of Wnt signaling pathway,which plays a multiple regulatory role in cardiac development and cardiac pathology.SFRP2 regulates cardiac development through bidirectional regulation of cardiomyocyte expansion and myocardial differentiation,and shows special temporal and spatial specificity.In the process of cardiac fibrosis,SFRP2 showed concentration dependence.Low concentration of SFRP2 promoted the progress of cardiac fibrosis,while high concentration of SFRP2 inhibited cardiac fibrosis.In the process of myocardial hypertrophy,sFRP2 can protect the myocardium from pathological hypertrophy.In terms of angiogenesis,SFRP2 can inhibit endothelial cell apoptosis caused by hypoxia,and promote endothelial cell migration,and induce endothelial angiogenesis,and promote vascular regeneration.In terms of cardiac regeneration therapy,s FRP2 can improve the survival ability of human mesenchymal stem cells(hMSCs)under oxidative stress and improve the therapeutic effect of stem cell transplantation.This paper reviews the role of SFRP2 in cardiac development and pathological changes of cardiovascular diseases.

关 键 词：分泌型卷曲相关蛋白2 WNT信号通路 心肌纤维化 心肌肥大 心血管再生 

分 类 号：R662[医药卫生—外科学]