慢性心力衰竭患者血浆半乳糖凝集素-3与动脉僵硬度的相关性  

Correlation between plasma galectin-3 level and arterial stiffness in patients with chronic heart failure

作　　者：许名东 李丽华 李晚泉 刘家超 李小丹 叶浩彬 陈健芳 邹文毕 XU Ming-dong;LI Li-hua;LI Wan-quan;LIU Jia-chao;LI Xiao-dan;YE Hao-bin;CHEN Jian-fang;ZOU Wen-bi(Department of Cardiology,Sanshui People’s Hospital,Foshan 528100,China)

机构地区：[1]佛山市三水区人民医院心血管内科,广东佛山528100

出　　处：《广东医科大学学报》2022年第2期169-172,共4页Journal of Guangdong Medical University

基　　金：佛山市科技攻关项目(1920001000275)。

摘　　要：目的分析慢性心力衰竭(CHF)患者血浆半乳糖凝集素-3(Gal-3)与动脉僵硬度的相关性。方法收集336例CHF患者及112例非CHF患者(对照组)临床资料、实验室检查和B超结果,ELISA检测血浆Gal-3水平,动脉硬化检测仪测定颈动脉和股动脉脉搏波传导速度(cf-PWV)、肱动脉和踝动脉脉搏波传导速度(ba-PWV)。结果LVEF、LVEDD、cf-PWV、ba-PWV、Gal-3、NT-proBNP在两组中差异均有统计学意义(P<0.01)。CHF组中,Gal-3与NTproBNP、cf-PWV、ba-PWV呈显著正相关(均P<0.01)。结论Gal-3、NT-proBNP和动脉僵硬度是CHF分级评估的重要指标并具有一定相关性。Objective To analyze the correlation between plasma galectin-3 level and arterial stiffness in patients with chronic heart failure(CHF).Methods Clinical,laboratory examination,and ultrasonography data were collected from 336 CHF and 112 non-CHF cases.Plasma galectin-3 content was detected by ELISA,and carotid/femoral artery(cf-PWV)and brachial/ankle artery pulse wave velocity(ba-PWV)was determined by arteriosclerosis detector.Results There were significant differences in LVEF,LVEDD,cf-PWV,ba-PWV,and levels of galectin-3 and NT proBNP between control and CHF groups(P<0.01).Galectin-3 level was positively correlated with NT proBNP content,cf-PWV,and ba-PWV(P<0.01)in CHF group.Conclusion Galectin-3,NT-proBNP and arterial stiffness are key indexes in evaluating CHF,and their correlation is also present in CHF patients.

关 键 词：半乳糖凝集素-3 动脉僵硬度 慢性心力衰竭 

分 类 号：R541[医药卫生—心血管疾病]