益肾促排卵汤对PCOS致排卵障碍性不孕患者的血清TGF-β1、性激素水平及子宫内膜容受性的影响  

Effect of Yishen ovulation decoction on serum TGF-β1,sex hormone levels and endometrial receptivity in infertility patients with ovulation dysfunction caused by PCOS

作　　者：孙玉香 袁慧 韩卓婷 SUN Yu-xiang;YUAN Hui;HAN Zhuo-ting(Department of Traditional Chinese Medicine;Department of Clinical Laboratory,The Second Affiliated Hospital of Guangdong Medical University,Zhanjiang524003,China)

机构地区：[1]广东医科大学附属第二医院中医科,广东湛江524000 [2]广东医科大学附属第二医院检验科,广东湛江524000

出　　处：《广东医科大学学报》2022年第2期187-189,共3页Journal of Guangdong Medical University

基　　金：湛江市非资助科技攻关专题(2020B01431)。

摘　　要：目的观察益肾促排卵汤对多囊卵巢综合征(PCOS)致排卵障碍性不孕患者的血清转化生长因子β(TGF-β_(1))、性激素水平及子宫内膜容受性的影响。方法70例PCOS致排卵障碍性不孕患者随机分为对照组和试验组,每组35例。对照组从月经周期的第5天起开始口服枸橼酸氯米芬片,1次/d,共服5 d。试验组在对照组的基础上加用益肾促排卵汤颗粒制剂,1剂/d,每次连续口服14 d。两组总疗程持续3个月经周期。比较两组患者治疗前后的中医证候评分、血清性激素睾酮(T)、促黄体生成素(LH)、TGF-β_(1)水平及子宫内膜容受性的变化。结果治疗后,试验组患者的中医证候评分、TGF-β_(1)、T、LH以及子宫动脉血流量指标PI和RI均低于对照组(P<0.05或0.01),子宫内膜厚度显著高于对照组(P<0.01)。结论益肾促排卵汤能有效改善PCOS致排卵障碍性不孕患者的子宫内膜容受性,调节性激素以及TGF-β_(1)水平,值得临床推广。Objective To study the effect of Yishen ovulation decoction on serum transforming growth factorβ(TGF-β_(1)),sex hormone levels and endometrial receptivity in patients with ovulatory dysfunction caused by polycystic ovary syndrome(PCOS).Methods 70 PCOS-induced infertility patients with ovulation dysfunction were randomly divided into Control group and Test group,35 cases in each group.Control group:starting from the 5th day of the menstrual cycle,clomiphene citrate tablets were taken orally once a day for 5 days.Test group:On the basis of the control group,the patients were added with Yishen Ovulation Decoction.Start taking it from the 5th day of the menstrual cycle,one dose per day,orally for 14 consecutive days each time,The two groups total course of treatment lasted for 3 menstrual cycles.The changes of TCM syndrome score,serum sex hormone testosterone(T),luteinizing hormone(LH),TGF-1 level and endometrial receptivity before and after treatment were compared between the two groups of patients.Result After treatment,The TCM syndrome score,serum TGF-β_(1),T,LH levels,uterine artery blood flow indexes PI and RI in the test group were lower than those in the control group(P<0.05 or 0.01),and the endometrial thickness was significantly higher than that in the control group(P<0.01).Conclusion Yishen ovulation decoction can effectively improve the endometrial receptivity and regulate the levels of sex hormones and TGF-β_(1) in infertility patients with ovulation dysfunction caused by PCOS.It is worthy of clinical application.

关 键 词：PCOS 益肾促排卵汤 子宫内膜容受性 TGF-β_(1) 性激素 

分 类 号：R271.14[医药卫生—中医妇科学]