急性胰腺炎发生急性肾损伤的早期预测指标  

Early predictors for acute kidney injury in acute pancreatitis

作　　者：王岩 李明政 刘玉凤 王世明[2] WANG Yan;LI Mingzheng;LIU Yufeng;WANG Shiming(Graduate School,Shanxi Medical University,Taiyuan 030001,China;Department of General Surgery,The First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学研究生院,太原030001 [2]山西医科大学第一医院普通外科,太原030001

出　　处：《临床肝胆病杂志》2022年第5期1192-1197,共6页Journal of Clinical Hepatology

摘　　要：急性胰腺炎(AP)是消化系统常见的急腹症之一,尽早治疗避免加重至重症急性胰腺炎(SAP)是保证预后的关键,AP合并急性肾损伤(AKI),使胰腺炎死亡率显著增加。早诊断AP并发AKI,是降低病死率的重中之重。本文综述了现有关于AP发生AKI早期预测指标的相关研究,相互比较,简述了中性粒细胞与淋巴细胞比率、胱抑素C、肾血管阻力指数、中性粒细胞明胶酶相关性脂质运载蛋白等常用指标以及其他有价值的指标,认为依据不同标志物的敏感度和特异度,多标志物联合诊断AP早期AKI是一大前景。Acute pancreatitis(AP)is one of the common acute abdominal diseases of the digestive system,and early treatment to avoid aggravation to severe pancreatitis(SAP)is the key to guaranteeing prognosis.AP with acute kidney injury(AKI)can significantly increase the mortality rate of pancreatitis.Early diagnosis of AP with AKI is a top priority to reduce mortality rate.This article reviews the current studies on the early predictors for AKI in AP and briefly describes commonly used indicators(neutrophil-to-lymphocyte ratio,cystatin C,renal vascular resistance index,and neutrophil gelatinase-associated lipocalin)and other valuable indicators.It is pointed out that a combination of various markers based on their sensitivity and specificity has a promising future in the diagnosis of AKI in AP.

关 键 词：胰腺炎 急性坏死性 急性肾损伤 炎症 早期诊断 

分 类 号：R69[医药卫生—泌尿科学]