疟原虫感染引起的炎症小体反应研究进展  

Advance in Responses of Inflammasomes Caused by Plasmodium Infection

作　　者：李昕 董彬 李承桓 袁泉 冯颖[1] 姜宁[1] LI Xin;DOONG Bin;LI Cheng-huan;YUAN Quan;FENG Ying;JIANG Ning(Shenyang Agricultural University,Shenyang,Liaoning,110161,China)

机构地区：[1]沈阳农业大学,辽宁沈阳110161

出　　处：《动物医学进展》2022年第5期92-96,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(81772219)。

摘　　要：炎症小体(inflammasome)是细胞感染或应激时激活的分子平台,可触发促炎细胞因子(如IL-1β)的成熟,从而参与先天免疫防御。炎症小体活性失调与人类遗传性和获得性炎症疾病之间的密切关系突出了这一途径在调节免疫反应中的重要性。疟原虫感染可触发多种先天免疫应答,其中疟原虫及其gDNA、RNA、疟色素(hemozoin,Hz)和糖基磷脂酰肌醇(glycosylphosphatidylinositols,GPIs)被免疫细胞捕获,激活AIM2、NLRP3或NLRC4等炎症小体,并生成TNF-α、IFN-γ、IL-12、IL-1β和IL-18等细胞因子,引起反复发热等疟疾的典型症状。疟原虫感染中的炎症小体反应是疟疾治疗的一个新兴研究方向,近年来相关研究受到了越来越多的关注,论文主要就近年来对疟原虫感染所引起机体的炎症小体反应进行综述,为疟疾治疗探索新的方向。Inflammasomes are molecular platforms that are activated when cells become infected or stressed,triggering the maturation of pro-inflammatory cytokines such as IL-1βthat are involved in innate immune defences.The close relationship between maladjusted inflammasome activity and inherited and acquired inflammatory diseases in humans highlights the importance of this pathway in modulating immune responses.Malaria infection triggers a variety of innate immune response,in which Plasmodium gDNA,RNA,hemozoin and glycosylphosphatidylinositols are captured by immune cells to activate AIM2,NLRP3 or NLRC4 inflamatosomes and produce a series of cytokines such as TNFα,IFNγ,IL-12,IL-1βand IL-18 leading to recurrent fever and other typical symptoms of malaria.In recent years,more and more attention has been paid to the research of inflammasomes response in malaria infection,which is an emerging field in malaria treatment.Here we discussed the inflammasomes caused by Plasmodium infection in recent years,and explored new directions for malaria treatment.

关 键 词：炎症小体 疟疾 先天免疫 

分 类 号：R531.3[医药卫生—内科学]