ALA-PDT联合强脉冲光治疗中重度痤疮疗效观察  

Therapeutic Effect of Photodynamic Therapy with 5-Aminolevulinic Acid Combined with Intense Pulsed Light for the Treatment of Moderate to Severe Acne

作　　者：章绮倩 李科成 张志丹[1] 谢姗[1] 谢光辉[1] ZHANG Qiqian;LI Kecheng;ZHANG Zhidan;XIE Shan;XIE Guanghui(Department of Plastic Surgery Laser Cosmetology,the First Affi liated Hospital of Jinan University,Guangzhou 510630,Guangdong,China)

机构地区：[1]暨南大学附属第一医院整形激光美容科,广东广州510630

出　　处：《中国美容医学》2022年第4期25-27,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的:观察5-氨基酮戊酸光动力联合强脉冲光治疗中重度痤疮的疗效与安全性。方法:选取2017年1月-2020年12月来笔者科室就诊的58例中重度痤疮患者,采用5-氨基酮戊酸光动力联合强脉冲光治疗,2周治疗1次,连续治疗3次。比较治疗前、治疗后2周、8周痤疮GAGS评分、瘢痕ECCA评分以及DLQI评分,观察疗效和安全性。结果:光动力联合强脉冲光治疗3次后,患者痤疮GAGS评分显著下降(P<0.05),差异有统计学意义;3个月随访有效率达93.10%,治疗后瘢痕ECCA及DLQI评分显著降低(P<0.05),差异有统计学意义。患者术中出现轻度疼痛,术后出现红斑、干燥紧绷及水肿,经对症处理后3~12 d缓解消退。结论:中重度痤疮采用光动力联合强脉冲光治疗效果显著,患者满意度高,安全性好,值得临床推广应用。Objective The aim of this study is to investigate the effectiveness and safety of photodynamic therapy(PDT) with 5-aminolevulinic acid(ALA)combined with intense pulsed light(IPL) for the treatment of moderate to severe acne. Methods From January 2017 to December 2020, a total of 58 patients with moderate to severe acne were selected from the Department of plastic surgery. They were treated with photodynamic therapy combined with intense pulsed light for three sessions with an interval of two weeks. The efficacy and safety of ALA-PDT combined with IPL were evaluated by the scores of GAGS, DLQI,ECCA grading scale of acne scars and adverse reactions on week 2 and 12 after the final treatment. Results After photodynamic combined with intense pulse light treatment for 3 times,GAGS score of patients with acne decreased significantly(P<0.05),and the difference was statistically significant.The effective rate of 3-month follow-up was 93.10%, and the ECCA and DLQI scores of scar were significantly decreased after treatment(P<0.05),the difference was statistically significant.The patients had mild pain during operation, erythema, dryness, tension and edema after operation, all disappeared within 3-12 days. Conclusion Photodynamic therapy with 5-aminolevulinic acid combined with intense pulsed light is safe and effective in the treatment of moderate and severe acne,which is worthy of clinical application.

关 键 词：光动力 5-氨基酮戊酸 强脉冲光 中重度痤疮 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]