天津市5170例泌尿生殖系统感染支原体检测及药敏结果分析  

Detection of Mycoplasma Infection and Antimicrobial Susceptibility Tests of Mycoplasma in 5 170 Samples of Urogenital System in Tianjin

作　　者：谷永革[1] 刘春莉[1] Gu Yongge;Liu Chunli(Tianjin Academy of Traditional Chinese Affiliated Hospital,Tianjin 300120,China)

机构地区：[1]天津市中医药研究院附属医院,天津300120

出　　处：《中国中西医结合皮肤性病学杂志》2022年第2期125-128,共4页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的 探讨天津地区泌尿生殖系统支原体及耐药状况,为临床诊疗及合理用药提供依据。方法 对2015年1月—2016年12月本院性病科及妇科就诊可疑患者(患者均有婚外性接触史或配偶感染史)共5 170例泌尿生殖系统支原体感染患者采用培养、鉴别、定量和药敏4种功能为一体的体外诊断试剂盒进行培养与药敏试验。结果 5 170例可疑泌尿生殖系统支原体感染患者中,支原体阳性者2 248例(43.48%),其中单一解脲脲原体(UU)阳性者1 435例(27.76%),单一人型支原体(MH)阳性者83例(1.61%),UU和MH混合感染例730例(14.12%),可见,支原体感染以UU感染为主,占总感染率的96.31%(2 165/2 248)。男性支原体阳性率为34.28%(892/2 602),女性支原体阳性率52.80%(1 356/2 568),女性支原体阳性率高于男性,差异有统计学意义(χ^(2)=180.413,P<0.01);药物敏感率超过50.00%的抗生素由高到低依次为美满霉素83.91%、强力霉素82.00%、交沙霉素62.09%、克拉霉素61.33%、氧氟沙星54.00%;药物耐药率由高到低依次为林可霉素94.53%、诺氟沙星75.56%、环丙沙星75.16%。结论 临床治疗泌尿生殖系统支原体感染时,宜选用美满霉素、强力霉素、交沙霉素、克拉霉素、氧氟沙星等药物治疗,尽量避免使用林可霉素、环丙沙星、诺氟沙星。本研究提示,临床工作中尽可能进行支原体培养与药敏试验,按照试验结果结合临床合理选用敏感抗生素,减少耐药的产生。Objective In order to understand the situation of UU and MH and drug resistance in Tianjin,and to provide scientific basis for the rational use of antibiotics in the clinic. Methods From January 2015 to December 2016,a total of 5 170 specimens in the suspicious patients with UU and MH in our department of sexually transmitted disease(STD) and department of gynecology were cultured, identified, quantified and tested for drug sensitivity with the in vitro diagnostic kit. Results Among 5 170 suspected cases of mycoplasma urogenital system(UU) and mycoplasma hominis(MH),2 248 cases(43.48%) Mycoplasma showed positive. And 1 435 cases(27.76%) were single UU positive,83 cases(1.61%) were single MH positive, and 730 cases(14.12%) were mixed. Visibly,the main mycoplasma infection was UU,accounting for 96.31%(2 165/2 248) of the total infection rate. The positive rate of mycoplasma in males was 34.28%(892/2 602) while in female was 52.80%(1 356/2 568). The positive rate of mycoplasma in females was higher than that in males,and there was statistically significant difference (χ^(2)=180.413,P<0.01). The drug sensitivity rate of more than 50% of antibiotics from high to low in order of minomycin 83.91%,doxycycline 82.00%,josamycin 62.09%,clarithromycin 61.33%,ofloxacin 54.00%. The drug rates were 94.53% lincomycin,75.56% norfloxacin and 75.16% ciprofloxacin. Conclusion Clinical treatment of UU and MH,should use minocycline,doxycycline,josamycin,clarithromycin,ofloxacin and so on,try to avoid the use of lincomycin,ciprofloxacin,and norfloxacin. This study suggests that the clinical use of antibiotics should be based on the mycoplasma culture and drug sensitivity test,in order to reduce the generation of drug resistance.

关 键 词：泌尿生殖系统 解脲脲原体 人型支原体 药敏试验 

分 类 号：R518.5[医药卫生—内科学]