Governing glutaminolysis by regulation of glutaminase succinylation  

作　　者：Qingxia Ma Hongfei Jiang Leina Ma Ying Meng Dong Guo Yingying Tong Zhimin Lu 

机构地区：[1]The Affliated Hospital of Qingdao University,Qingdao Cancer Institute,Qingdao University,Qingdao 266071,China [2]Zhejiang Provincial Key Laboratory of Pancreatic Disease,The First Affiliated Hospital,and Institute of Translational Medicine,Zhejiang University School of Medicine,Zhejiang University,Hangzhou 310029,China [3]Cancer Center,Zhejiang University,Hangzhou 310029,China [4]Cancer Center,Beijing Luhe Hospital,Capital Medical University,Beijing 101149,China

出　　处：《Protein & Cell》2022年第3期163-166,共4页蛋白质与细胞（英文版）

基　　金：This study was supported by grants from Ministry of Science and Technology of the People's Republic of China(2020YFA0803300,Z.L.);the National Natural Science Foundation of China(82188102,82030074,Z.L.;81902423,D.G.);the Zhejiang University Research Fund(188020*194221901/029,Z.L.);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01001,Z.L.);the Scientific Research Project of Beijing Municipal Education Commission(KM202110025002,Y.T.).Z.L.is the Kuancheng Wang Distinguished Chair.

摘　　要：Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA).

关 键 词：uniquely RESIDUES CRITICAL 

分 类 号：Q52[生物学—生物化学]