A nano-structured TiO_(2)/CuO/Cu_(2)O coating on Ti-Cu alloy with dual function of antibacterial ability and osteogenic activity  

作　　者：Yuan Zhang Shan Fu Lei Yang Gaowu Qin Erlin Zhang 

机构地区：[1]Key Laboratory for Anisotropy and Texture of Materials(MoE),School of Materials Science and Engineering,Northeastern University,Shenyang 110819,China [2]Research Center for Metallic Wires,Northeastern University,Shenyang 110819,China

出　　处：《Journal of Materials Science & Technology》2022年第2期201-212,共12页材料科学技术（英文版）

基　　金：financial support from the National Natural Science Foundation of China(No.31971253)。

摘　　要：Bacteria-associated infection and poor osseointegration are two main reasons for orthopedic implant failure.Ti-Cu alloy exhibited excellent antibacterial property,but still presented unsatisfied osteogenic activities.Therefore,Ti-Cu alloy was surface modified by an alkali-heat treatment in this paper to improve the osteogenic ability without reduction in antibacterial ability.A TiO_(2)/CuO/Cu_(2)O composite coating with nanostructure was deposited on Ti-Cu alloy.The coating showed increased roughness and great hydrophilicity.Antibacterial tests indicated that the modified Ti-Cu alloy exhibited stronger antibacterial ability against Staphylococcus aureus(S.aureus)than Ti-Cu alloy.Meanwhile,cell experiments demonstrated that the composite coating promoted initial adhesion and spreading of MC3T3-E1 cells,enhanced alkaline phosphatase(ALP)activities as well as extracellular matrix(ECM)mineralization,and significantly upregulated osteogenesis-related gene expressions.It was suggested that the nano-structured TiO_(2)/CuO/Cu_(2)O coating on Ti-Cu alloy might provide a potential strategy for orthopedic implant failure.

关 键 词：Ti-Cu alloy Alkali-heat treatment Antibacterial property Osteogenic activity 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TG146.23[金属学及工艺—金属材料]