Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multicentre registry network  

作　　者：James Guoxian Huang Yoko Kin Yoke Wong Kee Seang Chew Pornthep Tanpowpong Karen Sophia Calixto Mercado Almida Reodica Shaman Rajindrajith Kai-Chi Chang Yen-Hsuan Ni Suporn Treepongkaruna Way-Seah Lee Marion Margaret Aw 

机构地区：[1]Khoo Teck Puat-National University Children’s Medical Institute,National University Health System,Singapore 119228,Singapore [2]Department of Pediatrics,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 119228,Singapore [3]Epidemiology,Singapore Clinical Research Institute,Singapore 138669,Singapore [4]Department of Paediatrics,Faculty of Medicine,University Malaya,Kuala Lumpur 50603,Malaysia [5]Department of Pediatrics,Faculty of Medicine Ramathibodi Hospital,Mahidol University,Bangkok 10400,Thailand [6]Department of Pediatrics,Makati Medical Centre,Manila 1229,Philippines [7]Department of Pediatrics,The Medical City,Manila 0900,Philippines [8]Department of Pediatrics,Faculty of Medicine,University of Colombo,Colombo 00800,Sri Lanka [9]Department of Pediatrics,National Taiwan University Hospital,Taipei 100229,Taiwan

出　　处：《World Journal of Gastroenterology》2022年第17期1830-1844,共15页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease(PIBD).AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform.METHODS Clinical,endoscopic and radiologic data at diagnosis from the registry were extracted between 1^(st) January 1995 to 31^(st) December 2019.Disease phenotypic characteristics were classified as per the Paris classification system.RESULTS There was a distinct rise in new PIBD cases:Nearly half(48.6%)of the cohort was diagnosed in the most recent 5 years(2015-2019).The ratio of Crohn’s disease(CD):Ulcerative colitis(UC):IBDUnclassified was 55.9%:38.3%:5.8%.The mean age was 9.07 years with a high proportion of very early onset IBD(VEO-IBD)(29.3%)and EO-IBD(52.7%).An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort(6.8%-9.0%Indians in census).Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease(P=0.003).CD patients presented with significantly more constitutional symptoms(fever,anorexia,malaise/fatigue and muscle-wasting)than UC and higher inflammatory indices(higher C-reactive protein and lower albumin levels).CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity.South Asian CD patients were more likely to have symptomatic perianal disease.

关 键 词：ASIA Inflammatory bowel disease PAEDIATRICS Crohn’s disease Ulcerative colitis REGISTRY 

分 类 号：R725.7[医药卫生—儿科]