Association of maternal obesity and gestational diabetes mellitus with overweight/obesity and fatty liver risk in offspring  

作　　者：Jing Zeng Feng Shen Zi-Yuan Zou Rui-Xu Yang Qian Jin Jing Yang Guang-Yu Chen Jian-Gao Fan 

机构地区：[1]Department of Gastroenterology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [2]Shanghai Key Lab of Pediatric Gastroenterology and Nutrition,Shanghai 200092,China

出　　处：《World Journal of Gastroenterology》2022年第16期1681-1691,共11页世界胃肠病学杂志（英文版）

基　　金：Supported by Collaborative Innovation Program of Shanghai Municipal Health Commission, No. 2020CXJQ01;National Natural Science Foundation of China, No. 81873565 and No. 82100605;SJTU Trans-med Awards Research, No. 20190104;Star Program of Shanghai Jiao Tong University, No. YG2021QN54;WBE Liver Fibrosis Foundation, No. CFHPC2020061;Hospital Funded Clinical Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 17CSK04 and No. 15LC06

摘　　要：BACKGROUND Childhood obesity and fatty liver are associated with adverse outcomes such as diabetes,metabolic syndrome,and cardiovascular diseases in adulthood.It is very important to identify relevant risk factors and intervene as early as possible.At present,the relationship between maternal and offspring metabolic factors is conflicting.AIM To estimate the association of maternal obesity and gestational diabetes mellitus(GDM)with overweight/obesity and fatty liver risk in offspring at 8 years of age.METHODS The prospective study included mothers who all had a 75-g oral glucose tolerance test at 24-28 wk of gestation and whose offspring completed follow-up at 8 years of age.Offspring birth weight,sex,height,weight,and body mass index(BMI)were measured and calculated.FibroScan-502 examination with an M probe(Echosens,Paris,France)was prospectively conducted in offspring aged 8 years from the Shanghai Prenatal Cohort Study.RESULTS A total of 430 mother-child pairs were included in the analysis.A total of 62(14.2%)mothers were classified as obese,and 48(11.1%)were classified as having GDM.The mean age of the offspring at follow-up was 8 years old.Thirty-seven(8.6%)offspring were overweight,14(3.3%)had obesity,and 60(14.0%)had fatty liver.The prevalence of overweight,obesity and fatty liver in offspring increased significantly across maternal BMI quartiles(all P<0.05).Among offspring of mothers with GDM,12(25.0%)were overweight,4(8.3%)were obese,and 12(25.0%)had fatty liver vs.25(6.5%),10(2.6%)and 48(12.6%),respectively,for offspring of mothers without GDM(all P<0.05).In multiple logistic regression,after adjustment for variables,the OR for fatty liver in offspring was 8.26(95%CI:2.38-28.75)for maternal obesity and GDM.CONCLUSION This study showed that maternal obesity can increase the odds of overweight/obesity and fatty liver in offspring,and GDM status also increases the odds of overweight/obesity in offspring.Weight management and glycemic control before and during pregnancy need to be highlighted in primary pre

关 键 词：Maternal obesity Gestational diabetes mellitus Offspring overweight/obesity Offspring fatty liver FIBROSCAN 

分 类 号：R714.256[医药卫生—妇产科学]