AB016.Cholinergic enhancement reduces the temporary shift in perceptual eye dominance induced by a few hours of monocular occlusion  

作　　者：Yasha Sheynin Mira Chamoun Alex S.Baldwin Robert F.Hess Elvire Vaucher 

机构地区：[1]McGill Vision Research,Montreal,QC,Canada [2]Douglas Mental Health Institute,Montréal,QC,Canada [3]Universitéde Montréal,Montréal,QC,Canada

出　　处：《Annals of Eye Science》2019年第1期191-191,共1页眼科学年鉴（英文）

摘　　要：Background:A few hours of monocular deprivation with a diffuser eye patch temporarily strengthens the contribution of the deprived eye to binocular vision.This shift in favour of the deprived eye is characterized as a form of adult visual plasticity.Studies in animal and human models suggest that neuromodulators can enhance adult brain plasticity in general.Specifically,acetylcholine has been shown to improve certain aspects of visual function and plasticity in adulthood.We investigated whether a single administration of donepezil(a cholinesterase inhibitor)could further augment the temporary shift in perceptual eye dominance that occurs after two hours of monocular patching.Methods:We conducted three experiments to investigate whether donepezil enhances the shift in perceptual eye dominance induced by monocular patching.In each experiment,healthy adults completed two experimental sessions while taking either donepezil(5 mg,oral)or a placebo(lactose)pill.In experiment 1 we patched the non-dominant eye for 2 hours and measured ocular balance with a binocular phase combination task.In experiment 2 we patched for one hour to investigate whether donepezil shortens the amount of time necessary to observe a shift in ocular dominance.In experiment 3 we patched for 2 hours and measured ocular balance with a binocular rivalry task to see if the effect of donepezil was comparable across the two tasks.We calculated AUCs for the shift in perceptual eye dominance across five time points after removing the patch to compare our treatment conditions in each experiment.Results:Donepezil significantly reduces the magnitude and duration of the shift in perceptual eye dominance produced by both 2(P<0.01)and 1 hours(P<0.05)of monocular patching when measuring ocular balance with a binocular phase combination task.Donepezil also reduces the magnitude of the shift in ocular dominance when measuring balance with a binocular rivalry task.Conclusions:Previous studies have demonstrated that cholinergic potentiation enhances adult brain pla

关 键 词：Neural plasticity donepezil(Aricept) short-term monocular deprivation ocular dominance(OD) binocular combination binocular rivalry NEUROMODULATION excitatory/inhibitory balance(E/I balance) 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]