血清巨噬细胞炎症蛋白-2、MicroRNA-25水平变化与脓毒症患者病情程度的相关性及临床意义  

Correlation and Clinical Significance of Serum Macrophage Inflammatory Protein-2,MicroRNA-25 Levels and Severity of Illness in Patients with Sepsis

作　　者：温珂 WEN Ke(Department of Clinical Laboratory,the Second People's Hospital of Pingdingshan,Pingdingshan 467000,China)

机构地区：[1]平顶山市第二人民医院检验科,河南平顶山467000

出　　处：《河南医学研究》2022年第8期1470-1473,共4页Henan Medical Research

摘　　要：目的分析血清巨噬细胞炎症蛋白-2(MIP-2)、microRNA-25水平变化与脓毒症患者病情程度的相关性。方法选取平顶山市第二人民医院2019年8至2021年4月收治的89例脓毒症患者进行回顾性研究,均采用目标导向治疗方案复苏,根据治疗结果分为两组,其中完成复苏的47例患者纳入A组,未完成复苏的42例患者纳入B组。分别记录患者复苏前、复苏后6h、1d、3d、5d病情程度,病情程度采用急性生理与慢性健康评分(APACHEⅡ)进行评估,同时检测血清MIP-2、microRNA-25水平,比较两组复苏前后APACHEⅡ评分、血清MIP-2、microRNA-25水平动态变化情况。结果复苏后6h、1d、3d、5dA组APACHEⅡ评分较B组低(P<0.05);复苏后6h、1d、3d、5dA组血清MIP-2水平较B组低(P<0.05);复苏后6h、1d、3d、5dA组microRNA-25水平较B组高(P<0.05);血清MIP-2与脓毒症患者APACHEⅡ评分呈正相关关系,microRNA-25与脓毒症患者APACHEⅡ评分呈负相关关系(P<0.05)。结论脓毒症患者血清MIP-2、microRNA-25水平与患者疾病转归关系密切,血清MIP水平降低、microRNA-25水平提高提示患者病情程度缓解。通过临床血清水平检测有助于评估患者病情变化,为临床干预、预后评估提供依据,具有重要临床价值。Objective To analyze the correlation between serum levels of macrophage inflammatory protein-2(MIP-2)and microRNA-25 and the severity of sepsis.Methods A retrospective study was conducted on 89 sepsis patients in the Second People’s Hospital of Pingdingshan from August 2019 to April 2021.All of them were resuscitated by a goal-oriented treatment plan.According to the treatment results,they were divided into two groups.Among them,47 patients who completed the resuscitation were included in group A,and 42 patients who did not complete resuscitation were included in group B.The patients’condition before and 6 h,1 d,3d and 5 d after resuscitation were recorded.The severity was assessed by acute physiology and chronic health evaluation H(APACHE H)score.At the same time,serum MIP-2 and microRNA-25 levels were detected,and APACHE H score,serum MIP-2 and microRNA-25 levels were compared between the two groups before and after resuscination.Results At 6 h,1d,3d and 5d after resuscitation,the APACHE H score of group A was lower than that of group B(P<0.05).The serum MIP-2 level of group A was lower than that of group Bat6h,1 d,3d and 5 d after resuscitation(P<0.05).At6h,1 d,3d,5 d after resuscitation,the level of microRNA-25 in group A was higher than that in group B(P<0.05).Serum MIP-2 was positively correlated with the APACHE H score of sepsis patients.There was a negative correlation between microRNA-25 and APACHE H score in sepsis patients(P<0.05).Conclusion Serum MIP-2 and microRNA-25 levels in patients with sepsis are closely related to the patient’s disease outcome.The decrease in serum MIP level and the increase in microRNA-25 level indicate that the patient’s condition is relieved.The clinical serum level test is helpful to assess the patient’s condition changes.Provide basis for clinical intervention and prognosis assessment,and have important clinical value.

关 键 词：脓毒症 巨噬细胞炎症蛋白-2 microRNA-25 病情程度 

分 类 号：R446[医药卫生—诊断学]