甘草酸二铵注射液联合异甘草酸镁治疗病毒性肝炎的效果及安全性  

Efficacy and safety of diammonium glycyrrhizinate injection combined with magnesium isoglycyrrhizinate in the treatment of viral hepatitis

作　　者：车钰 赵伟锋 CHE Yu;ZHAO Weifeng(Hepatobiliary Surgery Department;Gastroenterology Department,Tongchuan Mining Bureau Central Hospital Affiliated to Shaanxi University of Chinese medicine,Tongchuan 727000,China)

机构地区：[1]陕西中医药大学附属铜川矿务局中心医院肝胆外科,陕西铜川727000 [2]陕西中医药大学附属铜川矿务局中心医院消化内科,陕西铜川727000

出　　处：《临床医学研究与实践》2022年第14期67-70,共4页Clinical Research and Practice

摘　　要：目的探讨甘草酸二铵注射液联合异甘草酸镁治疗病毒性肝炎的效果及安全性。方法选取我院2018年12月至2020年12月收治的108例病毒性肝炎患者为研究对象,采用随机数字表法将其分为对照组与观察组,每组54例。对照组给予甘草酸二铵注射液治疗,观察组在对照组基础上加用异甘草酸镁治疗。比较两组的临床疗效、肝功能指标、炎性因子、临床指标、临床症状评分以及不良反应发生情况。结果观察组的治疗总有效率为96.30%,明显高于对照组的79.63%,差异具有统计学意义(P<0.05)。治疗前,两组患者的TBIL、AST及ALT水平无显著差异(P>0.05);治疗后,两组患者的TBIL、AST及ALT水平均显著降低,且观察组显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者的TNF-α、IL-6及IL-10水平无显著差异(P>0.05);治疗后,两组患者的TNF-α、IL-6及IL-10水平均显著降低,且观察组显著低于对照组,差异具有统计学意义(P<0.05)。观察组的肝功能指标恢复正常时间、病毒转阴时间显著短于对照组,感知疲劳、食欲不振、上腹不适评分显著低于对照组,差异具有统计学意义(P<0.05)。两组患者用药期间的不良反应总发生率比较,差异不具有统计学意义(P>0.05)。结论甘草酸二铵注射液联合异甘草酸镁联合治疗病毒性肝炎的临床效果显著,可有效改善患者的肝功能指标,减轻炎症反应,加快疾病康复速度,缓解临床症状,且用药安全性较高。Objective To explore the efficacy and safety of diammonium glycyrrhizinate injection combined with magnesium isoglycyrrhizinate in the treatment of viral hepatitis.Methods A total of 108 patients with viral hepatitis treated in our hospital from December 2018 to December 2020 were selected as the research objects and divided into control group and observation group using random number table method,with 54 cases in each group.The control group was treated with diammonium glycyrrhizinate injection,and the observation group was treated with magnesium isoglycyrrhizinate on the basis of the control group.The clinical efficacy,liver function indexes,inflammatory factors,clinical indexes,clinical symptom scores and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.30%,which was significantly higher than 79.63%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of TBIL,AST and ALT between the two groups(P>0.05);after treatment,the levels of TBIL,AST and ALT in the two groups significantly decreased,and those in the observation group were significantly lower than the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of TNF-α,IL-6 and IL-10 between the two groups(P>0.05);after treatment,the levels of TNF-α,IL-6 and IL-10 in the two groups significantly decreased,and those in the observation group were significantly lower than the control group,and the differences were statistically significant(P<0.05).The recovery time of liver function indexes and the time of virus turning negative in the observation group were significantly shorter than those in the control group,and the scores of perceived fatigue,loss of appetite and upper abdominal discomfort in the observation group were significantly lower than those in the control group,and the di

关 键 词：甘草酸二铵注射液 异甘草酸镁 病毒性肝炎 肝功能 炎症反应 

分 类 号：R512.6[医药卫生—内科学]