MrOS(Hong Kong)与MsOS(Hong Kong)研究显示老年华人脊柱更加健康  

MrOS(Hong Kong)and MsOS(Hong Kong)studies show elderly Chinese have a general healthier spine

作　　者：王毅翔[1] 梁志信 郭志銳 WANG Yi-xiang;LEUNG Jason CS;KWOK Timothy CY(Faculty of Medicine,Chinese University of Hong Kong,Shatin,Hong Kong SAR,China)

机构地区：[1]香港中文大学医学院,中国香港特别行政区沙田

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2022年第1期98-106,共9页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：MrOS(osteoporotic fractures in men,Hong Kong)和MsOS(osteoporotic fractures in women,Hong Kong)分别是男性及女性东亚人骨骼健康的首次基于社区人群的大规模前瞻性队列研究。在基线时,2001年至2003年招募了居住在中国香港社区的2000名华人男性和2000名华人女性平均年龄:男性(72.3±5.01)岁,女性(72.5±5.36)岁]受试者进行脊柱X线片、骨密度及其他相关临床指标采集,迄今已随访20年。第4年随访有1519名男性和1546名女性参加了脊柱X线检查;第14年随访271名男性和150名女性进行了全脊柱磁共振检查。本文总结本团队已经发表的脊柱X线研究结果,并与其他作者文献对比分析。本研究结果显示,按照终板和/或皮质骨折(endplate and/or cortex fracture,ECF)标准,-1、-2和-3级骨质疏松性椎体骨折(osteoporotic vertebral fracture,OVF)基线时的发生率男性分别为1.89%、1.74%和2.25%,女性分别为3.33%、3.07%、5.89%。在第4年随访时,有基线OVF的男性受试者进一步OVF的风险几乎没有增加,基线无OVF受试者及基线有OVF受试者第4年新骨折发生率分别为2.05%及2.49%;而有基线OVF的女性受试者第4年随访时进一步发生OVF的风险显著增加,基线无OVF受试者及基线有OVF受试者第4年新骨折发生率分别为4.56%及15.65%。比较年龄匹配的中国香港地区华人女性和意大利高加索女性社区人群平均年龄均为(74.1±6.14岁)],发现中国受试者ECF发病率为26%而意大利受试者为47%,意大利受试者的OVF可能更多发、而且通常更严重。本团队数据整合表明,高加索人老年退行性椎体滑脱的患病率比中国香港地区华人老年人高60%~70%。文献分析显示,与高加索人相比,东亚人尤其是中国人的背痛发生率更低。上述数据表明,与老年高加索人相比,中国老年人的脊柱总体上更健康。The MrOS(osteoporotic fractures in men,Hong Kong)and MsOS(osteoporotic fractures in women,Hong Kong)studies represent the first large-scale prospective cohort studies on bone health in East Asian men and women.At baseline,community-dwelling 2000 Chinese men and 2000 Chinese women(mean:72.3±5.01 years for men and 72.5±5.36 years for women)were recruited and studied during 2001 to 2003.These two studies have spanned two decades till now.The 4 years follow-up(FU)had 1519 men and 1546 women attended spine radiograph,and 14 years FU had spine MRI for 271 men and 150 women.This review summarizes our published spine radiograph results and makes comparison with the reports of other authors.With endplate and/or cortex fracture(ECF)criteria,grade-1,-2,and-3 OVF(osteoporotic vertebral fracture)baseline prevalence was 1.89%,1.74%,and 2.25%in men,and 3.33%,3.07%,and 5.89%in women.For 4 years FU,male participants with baseline OVF had little increased risk for further OVF,with those without baseline OVF and those with baseline OVF had new OVF observed among 2.05%and 2.49%participants respectively.On the other hand,female participants with baseline OVF had significantly increased risk for further OVF at year-4 FU,with those without baseline OVF and those with baseline OVF had new OVF observed among 4.56%and 15.65%participants respectively.In our study comparing OVF prevalence in age-matched Hong Kong Chinese and Italian Caucasian women(both mean age:74.1±6.14 years),the ECF prevalence was 26%for Chinese subjects and 47%for Italian subjects respectively.OVFs in Italian subjects were more likely to be multiple and generally severer.Our data synthesis suggests elderly Caucasians have higher degenerative spondylolisthesis prevalence,being 60%-70%higher,than elderly Hong Kong Chinese.An analysis of literature shows,compared with Caucasians,Asians particularly Chinese have a lower prevalence of back pain.We argue that elderly Chinese have a generally healthier spine relative to elderly Caucasians.

关 键 词：脊柱 骨质疏松性椎体骨折 退行性脊椎滑脱 腰背痛 华人 高加索人 

分 类 号：R681[医药卫生—骨科学]