合成手性(S)-3-羟基-3-苯基丙腈的实验教学实践  

Experimental Teaching Practice on Synthesis of Chiral(S)-3-hydroxy-3-phenylpropionitrile

作　　者：郭庆君 Guo Qingjun(School of Chemistry,Chemical Engineering and Materials,Ji’ning University,Qufu 273155,China)

机构地区：[1]济宁学院化学化工与材料学院,山东曲阜273155

出　　处：《广东化工》2022年第8期229-231,共3页Guangdong Chemical Industry

摘　　要：为提升学生科研能力,优选合成手性醇的综合实验,使用特别的催化剂,在常温常压水溶液中,用甲酸还原苯甲酰乙腈制备(S)-3-羟基-3-苯基丙腈的路线。它包含薄层色谱检测反应的进程,也有产物的萃取、洗涤、干燥、旋转蒸干分离纯化过程,更有高效液相色谱仪测量光学异构体过量值(e.e.)经过,再加上产品进行元素分析得到化学实验式、核磁共振波谱表征产品结构和测比旋光度进行比对确定产物的历程。整个过程完全的实践了化学合成研究的一般方法,体验科学研究的基本流程,同时也学习和掌握实验知识和技能。In order to improve the students’ scientific research ability and optimize the synthesis of chiral alcohols, a special catalyst was used to prepare(S)-3-hydroxy-3-phenylpropionitrile by reducing benzoyl acetonitrile with formic acid in an aqueous solution at room temperature and atmospheric pressure. It consists of a thin layer chromatography detection reaction process, there is also a product of extraction, washing, drying, spinning top up purification process, the more highly effective liquid phase color spectrometer to measure the optical isomer through value(e.e.), plus products by chemical element analysis, empirical formula, nuclear magnetic resonance(NMR) spectral characterization of the product structure and compares than polarimetric measurement to determine the product process. During the whole process, the general method of chemical synthesis research is completely practiced, the basic process of scientific research is experienced, and the experimental knowledge and skills are also learned and mastered.

关 键 词：合成 手性 实验 教学 催化剂 

分 类 号：O625.67[理学—有机化学]