急性非ST段抬高型心肌梗死患者血清同型半胱氨酸水平与SYNTAX评分的关系  

The relationship between serum homocysteine levels and SYNTAX score in patients with non-ST-segment elevation myocardial infarction

作　　者：王雅洁[1] 林文华[1] 敬锐[1] 刘菁晶[1] 卢宇杰[1] Wang Yajie;Lin Wenhua;Jing Rui;Liu Jingjing;Lu Yujie(First department of internal medicine, TEDA International Cardiovascular Hospital, Tianjin 300457, China)

机构地区：[1]泰达国际心血管病医院内一科,天津300457

出　　处：《临床荟萃》2022年第4期325-328,共4页Clinical Focus

摘　　要：目的探讨急性非ST段抬高型心肌梗死(NSTEMI)患者血清同型半胱氨酸水平与STNTAX评分(SS)之间的关系。方法对298例NSTEMI患者进行回顾性分析,对患者总体特征、包括血清同型半胱氨酸水平(HCY)在内的多项化验指标和在院期间超声左心室射血分数等辅助检查结果以及冠状动脉造影后所计算的SS进行统计及分析。依据计算出的SS将入选患者分为3组,低SS组:SS≤22;中等SS组:22<SS<33;高SS组:SS≥33,分析并比较3组相关数据。结果入组的298例NSTEMI患者包括低SS组177例(59.4%),中等SS组77例(25.8%),高SS组44例(14.8%)。血清HCY水平在低SS组为(16.1±9.1)μmol/L,中等SS组为(20.3±9.1)μmol/L,高SS组为(27.5±9.5)μmol/L。中等SS组和高SS组的HCY水平明显高于低SS组(P<0.01)。相关分析显示血清HCY水平与SS相关(r=0.358,P<0.01)。结论NSTEMI患者的血清HCY水平与冠状动脉病变严重程度有关。Objective To explore the relationship between serum homocysteine(HCY)levels and SYNTAX score(SS)in patients with non-ST-segment elevation myocardial infarction(NSTEMI).Methods We performed a retrospective analysis of 298 patients with NSTEMI from the aspects of general clinical features,multiple laboratory indicators including serum HCY level,left ventricular ejection fraction(LVEF)and SS on the echocardiography during hospitalization.SS was also calculated according to the images of angiography for further statistical analysis.The patients were divided into three groups according to the SS value:low-(SS≤22),medium-(22<SS<33),high-SS group(SS≥33),with a comparison of interclass correlation from related data.Results The enrolled 298 NSTEMI patients consisted of 177 patients(59.4%)in the low-SS group,77(25.8%)in the medium-SS group,and 44(14.8%)in the high-SS group.Serum HCY levels were(16.1±9.1)μmol/L,(20.3±9.1)μmol/L,(27.5±9.5)μmol/L in low-,medium-,and high-SS groups,respectively.Serum HCY levels in medium-,high-SS groups were significantly higher than those in low-SS group(P<0.01).The related analysis indicated homocysteine levels were correlated with SS(r=0.358,P<0.01).Conclusion Serum HCY levels were associated with increasing severity of coronary artery disease in the patients with NSTEMI.

关 键 词：非ST段抬高型心肌梗死 同型半胱氨酸 SYNTAX评分 

分 类 号：R541.4[医药卫生—心血管疾病]