不同β受体阻滞剂外用联合脉冲染料激光治疗婴儿血管瘤临床疗效观察  

Clinical observation of external application of different beta blockers combined with pulsed dye laser in treatment of infantile hemangiomas

作　　者：王攀 郑源泉[1] 卢静静[1] 付桂莉[1] WANG Pan;ZHENG Yuan-quan;LU Jing-jing(Department of Dermatology,Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital),Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430016,China)

机构地区：[1]华中科技大学同济医学院附属武汉儿童医院,武汉430016

出　　处：《实用皮肤病学杂志》2022年第1期14-17,共4页Journal of Practical Dermatology

基　　金：武汉市卫生计生委科研计划资助项目(WX18Q45)。

摘　　要：目的对比0.5%马来酸噻吗洛尔滴眼液和2%卡替洛尔滴眼液分别联合脉冲染料激光(595nm)治疗中低风险、浅表性婴儿血管瘤的临床疗效及安全性。方法收集符合入组标准的患儿241例,随机分为噻吗洛尔联合激光治疗组123例,卡替洛尔联合激光治疗组118例;观察临床疗效及不良反应。结果噻吗洛尔联合激光组患儿在治疗后1、3,6个月有效率分别为28.46%、82.11%、91.87%;卡替洛尔联合激光组患儿有效率分别为27.97%、62.25%、88.98%。两组治疗后的第1、第6个月有效率相比差异无统计学意义(P>0.05),治疗后第3个月有效率相比差异有统计学意义(P<0.05)。两组随着治疗时间的增加,治疗有效率均逐渐增加,疗程和疗效呈正相关(P<0.05)。不良反应包括湿疹和溃疡,其他系统未出现严重的不良反应。比较两组治疗6个月后不良反应,其中噻吗洛尔联合激光组不良反应率为8.13%、卡替洛尔联合激光组不良反应率为9.32%,两组相比差异无统计学意义(P>0.05)。结论在中低风险浅表性婴儿血管瘤的治疗中,噻吗洛尔联合激光相较于卡替洛尔联合激光治疗血管瘤增殖早期能够更快、更好地控制其生长,提高临床治疗有效率;但起效时间和远期疗效两种治疗方法有效率相当,随着疗程增加,疗效增高。两组不良反应发生率低,均具有较好的临床疗效和安全性。Objective To explore the clinical efficacy and safety of 0.5%timolol maleate eye drops and 2%carteolol eye drops combined with pulsed dye laser(595nm)in the treatment of low-and medium-risk,superficial and proliferative infantile hemangioma.Methods 241children with hemangioma in outpatient who met the enrollment criteria were collected.These 241 pediatric patients were randomly divided into timolol combined with pulsed laser treatment group(123 cases)and the carteolol combined with pulsed dye laser treatment group(118 cases).Clinical efficacy and adverse reactions were observed in this study.Results The effective rates in the timolol combined with pulsed laser treatment group were 28.46%,82.11%,and 91.87%after 1,3,and 6 months after treatment,the carteolol combined with pulsed dye laser treatment group were 27.97%,62.25%,88.98%.There was no statistical difference in the effective rate between the two groups at the first and sixth month after treatment(P>0.05),but it was statistically different at the third month after the treatment(P<0.05).With the increase of treatment time,the effective rate of treatment increased gradually in both groups(P<0.05).Treatment-related adverse reactions included local eczema and ulcers,and no systemic adverse reactions occurred.The incidence of treatment-related adverse reactions between the two groups was compared,in which the timolol combined with pulsed laser treatment group was 8.13%,and the carteolol combined with pulse dye laser treatment group was 9.32%.There was no significant difference between the two groups(P>0.05).Conclusion Compared with carteolol combined with pulsed dye laser treatment,timolol combined with pulsed dye laser can inhibit the growth of hemangioma in the early proliferation stage faster and better,and improve the clinical treatment efficiency of low-and medium-risk superficial infantile hemangioma.But the onset time and long-term curative effect are similar in the two groups.The two treatments have low incidence of adverse reactions,and both showed good c

关 键 词：血管瘤 噻吗洛尔 卡替洛尔 激光 595nm脉冲染料 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]