抗-HBc定量测定在乙型肝炎病毒慢性感染性疾病中的应用  

Application of anti-HBc quantitative examination in clinical management of chronic hepatitis B virus infection

作　　者：杜心怡 毛小荣[2] 李俊峰[2] DU Xin-yi;MAO Xiao-rong;LI Jun-feng(The First Clinical Medical College, Lanzhou University, Lanzhou 730000;Department of Infection,the First Hospital, Lanzhou University, Lanzhou 730000, China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院感染科,甘肃兰州730000

出　　处：《基础医学与临床》2022年第5期804-808,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81800528);甘肃省自然科学基金(20JR5RA364);甘肃省重点研发计划(21YF5FA121);甘肃省感染肝病临床医学研究中心(21JR7RA392)。

摘　　要：乙肝病毒核心抗体(抗-HBc)与机体免疫相关,在现症及既往乙型肝炎病毒(HBV)感染者血清中均可测得,其在HBV自然史的判断及治疗策略中可发挥巨大作用。HBV感染慢性化与肝内共价闭合环状DNA(cccDNA)活跃转录和持续存在密切相关;抗-HBc定量与cccDNA水平有较好相关性,可作为综合评价HBV感染性疾病的一项指标。The quantification of hepatitis B virus(HBV)core antibody(anti-HBc)is related to host immunity and can be detected in the serum of patients with current or past infections.The antibody against core antigen of HBV plays an important role in the inflammation pathogenesis of liver,evaluation of epidemiology history and of treatment strategy.Chronic HBV infection is closely related to active transcription and persistence of covalently closed circular DNA(cccDNA)in the liver.The result of quantitative anti-HBc antibody examination shows a good correlation with cccDNA level so it is a potential index for comprehensive evaluation of HBV infectious diseases.

关 键 词：乙型肝炎病毒(HBV) 共价闭合环状DNA 乙肝病毒核心抗体定量 慢性感染 

分 类 号：R512.6[医药卫生—内科学]