中性粒细胞淋巴细胞比值与非体外循环冠状动脉旁路移植术后新发房颤相关性研究  

Study on the correlation between neutrophil to lymphocyte ratio and atrial fibrillation after off-pump coronary artery bypass grafting

作　　者：孙广龙[1] 仲昭澎 伯平[1] 高竣迪 穆军升[1] SUN Guang-long;ZHONG Zhao-peng;BO Ping;GAO Jun-di;MU Jun-sheng(Department of Cardiac surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院心脏外科,北京市100029

出　　处：《中国心血管病研究》2022年第4期340-343,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的 初步探讨中性粒细胞淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)与非体外循环冠状动脉旁路移植术(off-pump coronary artery bypass grafting,OPCABG)术后新发心房颤动(atrial fibrillation,AF)的相关性。方法 回顾性分析2021年1月1日至12月31日135例由单一治疗组行OPCABG患者的临床资料,根据术后是否发生AF分为AF组与非AF组,分析患者的性别、年龄、EuroSCOREⅡ评分、手术前后超声学相关指标、术前及术后第1 d的NLR,分析不同组别NLR值及其他因素与术后新发AF之间的关系。结果 两组之间在年龄、术前EuroSCOREⅡ评分及术后NLR存在显著性差异(P<0.05),AF组的年龄[(65.7±6.7)岁比(61.7±9.1)岁]、EuroSCOREⅡ评分[(2.9±2.5)分比(2.2±1.2)分]及术后NLR水平[(14.7±10.8)mm比(11.3±5.7)mm]均高于非AF组。术后平均随访时间为(6.9±3.3)个月,无新增死亡病例,1例患者术后半年因“病窦综合征”行人工起搏器置入,其余患者无再发AF。结论 NLR作为一种新型的炎症评价指标,与AF的发生密切相关,术后NLR越高,OPCABG术后发生AF的概率越高。Objective To investigate the relationship between neutrophil to lymphocyte ratio(NLR) and new onset atrial fibrillation(AF) after off-pump coronary bypass grafting(OPCABG).Methods A retrospective analysis was performed on the clinical data of 135 patients who received OPCABG from January 1,2020 to December 31,2020.The patients were divided into two groups(AF group and non-AF group) according to whether atrial fibrillation occurred after the operation.The gender,age,EuroSCOREⅡ score,data of ultrasound before and after the surgery,NLR before and on the first day after the operation were analyzed.The relationship between NLR and other factors and new onset AF after operation was analyzed.Results There were significant differences in age,preoperative EuroSCOREⅡ values and postoperative NLR between the two groups(P<0.05).The age [(65.7 ± 6.7) years vs.(61.7 ± 9.1) years],EuroSCORE Ⅱ [(2.9 ± 2.5) scores vs.(2.2 ± 1.2) scores] and postoperative NLR levels [(14.7 ± 10.8) mm vs.(11.3 ± 5.7) mm] in AF group were higher than those in non-AF group.Conclusions As a new inflammatory evaluation index,NLR is closely related to the occurrence of atrial fibrillation after OPCABG.The higher the postoperative NLR is,the higher the incidence of the atrial fibrillation is.

关 键 词：中性粒细胞淋巴细胞比值 非体外循环冠状动脉旁路移植术 心房颤动 

分 类 号：R654.2[医药卫生—外科学]